NDLI: Longitudinal association of preference-weighted health-related quality of life measures and substance use disorder outcomes.

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Longitudinal association of preference-weighted health-related quality of life measures and substance use disorder outcomes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pyne, Jeffrey M. Tripathi, Shanti French, Michael McCollister, Kathryn Rapp, Richard C. Booth, Brenda M.
Spatial Coverage	United States
Description	Country affiliation: United States Author Affiliation: Pyne JM ( Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, Little Rock, USA. jmpyne@uams.edu)
Abstract	AIM: To examine the construct validity of generic preference-weighted health-related quality of life measures in a sample of patients with a substance use disorder (SUD). DESIGN: Longitudinal (baseline and 6-month follow-up) data from a research study that evaluated interventions to improve linkage and engagement with SUD treatment. SETTING: A central intake unit that referred patients to seven SUD treatment centers in a Midwestern US metropolitan area. PARTICIPANTS: A total of 495 individuals with a SUD. MEASUREMENTS: Participants completed two preference-weighted measures: the self-administered Quality of Well-Being scale (QWB-SA) and the standard gamble weighted Medical Outcomes Study SF-12 (SF-6D). They were also administered two clinical assessments: all seven domains of the Addiction Severity Index (ASI) and a symptom checklist based on the DSM-IV. Construct validity was determined via the relationships between disease-specific SUD and generic measures. FINDINGS: In unadjusted analyses, the QWB-SA and SF-6D change scores were correlated significantly with six ASI subscale change scores, but not with employment status. In adjusted repeated-measures analyses, three of seven ASI subscale scores were significant predictors of QWB-SA and 5/7 ASI subscale scores were significant predictors of SF-6D. Abstinence and problematic use at follow-up were significant predictors of QWB-SA and SF-6D. Effect sizes ranged from 0.352 to 0.400 for abstinence and -0.484 to -0.585 for problematic use. CONCLUSIONS: Generic preference-weighted health-related quality of life measures show moderate to good associations with substance-use specific measures and in certain circumstances can be used in their stead. This study provides further support for the use of the Quality of Well-Being scale and Medical Outcomes Study SF-12 in clinical and economic evaluations of substance use disorder interventions.
File Format	HTM / HTML
ISSN	09652140
e-ISSN	13600443
DOI	10.1111/j.1360-0443.2010.03299.x
Journal	Addiction
Issue Number	3
Volume Number	106
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Therapy Psychology Cost-benefit Analysis Discipline Addiction Patient Acceptance Of Health Care Outcome Assessment (health Care) Quality Of Life Substance-related Disorders Questionnaires Validation Studies Severity Of Illness Index Research Support, U.s. Gov't, Non-p.h.s. Substance Abuse Treatment Centers Data Interpretation, Statistical Diagnostic And Statistical Manual Of Mental Disorders Quality-adjusted Life Years Adolescent Health Status Longitudinal Studies
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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