NDLI: First-trimester assessment of nasal bone using retronasal triangle view: a prospective study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Adiego, B. Martinez-Ten, P. Illescas, T. Bermejo, C. Sepulveda, W.
Description	Country affiliation: Spain Author Affiliation: Adiego B ( Delta-Ultrasound Diagnostic Center in Obstetrics and Gynecology, Madrid, Spain.)
Abstract	OBJECTIVE: To examine the feasibility and accuracy of fetal nasal bone (NB) assessment in the retronasal triangle (RNT) view for aneuploidy screening in the first trimester of pregnancy. METHODS: Consecutive women with singleton pregnancies undergoing sonographic screening at 11-13 weeks' gestation were prospectively evaluated. In all cases, assessment of the NB by using the RNT view was attempted and classified as present (if one or both of the NBs were clearly seen) or absent/hypoplastic (if the NB was not visualized or if it was small and less echogenic than the surrounding bones). The detection rate of fetal karyotypic abnormalities by the assessment of the NB in the RNT view was calculated. RESULTS: In total, 1977 women were scanned. The RNT was successfully examined in 1970 fetuses (99.6%). Fetal outcome was available in 1767 (89.7%) of evaluated cases, and of these, 39 (2.2%) cases of aneuploidy were documented (trisomy 21, n=17; trisomy 18, n=8; trisomy 13, n=5; Turner syndrome, n=5; and triploidy, n=4). The prevalence of absent/hypoplastic NB was 12/1728 (0.7%) in chromosomally normal fetuses and 12/17 (70.6%) in trisomy 21 fetuses. Sensitivity, specificity and positive and negative predictive values of absent/hypoplastic NB for trisomy 21 were 70.6%, 99.3%, 50.0% and 99.7%, respectively. The positive and negative likelihood ratios of NB assessment were 101 (95% CI, 53-193) and 0.3 (95% CI, 0.14-0.62), respectively. CONCLUSIONS: The RNT view is a useful technique for assessing the NB during the first trimester of pregnancy. With this new approach, performance of absent/hypoplastic NB as a marker of aneuploidy, mainly trisomy 21, appears to be similar to that previously reported by using the mid-sagittal plane.
Related Links	http://onlinelibrary.wiley.com/doi/10.1002/uog.12525/full
File Format	HTM / HTML
ISSN	09607692
Volume Number	43
Journal	Ultrasound in Obstetrics & Gynecology
e-ISSN	14690705
Issue Number	3
DOI	10.1002/uog.12525
Language	English
Publisher	Wiley
Publisher Date	2014-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Obstetrics Discipline Gynecology Aneuploidy Nasal Bone Abnormalities Pregnancy Trimester, First Prenatal Diagnosis Adult False Positive Reactions Feasibility Studies Female Humans Karyotyping Maternal Age Embryology Nuchal Translucency Measurement Practice Guidelines As Topic Pregnancy Pregnancy Outcome Methods Prospective Studies Reproducibility Of Results Risk Factors Evaluation Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Reproductive Medicine Radiological and Ultrasound Technology Obstetrics and Gynecology

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