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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Oloyede, Olufemi Adebari Abbey, Mkpe Oloyede, Adeniyi Adebowale Nwachukwu, Onyinye |
| Spatial Coverage | Nigeria |
| Description | Country affiliation: Nigeria Author Affiliation: Oloyede OA ( Fetal Medicine Unit, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria ); Abbey M ( Whipps Cross University Hospital, London.); Oloyede AA ( Manor Hospital, Walsall, United Kingdom.); Nwachukwu O ( High Rocks Fetal Medicine and Genetic Diagnosis Centre, Oshodi, Lagos, Nigeria.) |
| Abstract | INTRODUCTION: To evaluate the performance of first trimester nuchal translucency scan screening among pregnant women in Nigeria. METHODS: A prospective observational and questionnaire based study involving 510 pregnant women between 11(+0) and 13(+6) weeks. Routine counselling and nuchal translucency measurement was conducted using the FMF, London guidelines. Chorionic villous sampling was done at NT ≥ 2.5 mm or ≥ 95th centile. RESULTS: Five hundred and ten out of 542 (94.1%) were analysed, mainly referred by health care workers (87.2%) and from predominantly private facilities (94.3%). The number of NT scans performed increased in successive years with corresponding decrease in the mean scanning time. Scan was successfully completed at first attempt in (96.5%), with mean scanning time of 28.3 minutes. Nuchal translucency increases with gestational but not maternal age. The median and 95th centile at 11(+0) week was 1.2mm and 1.7 mm and at 13(+6) weeks was 1.5 mm and 2.2 mm. Using a cut-off of ≥ 2.5 mm or ≥ 95th centile, 17 (3.3%) screened positive. Three out of the 17 had invasive testing and 2 (DR = 66.7%) were confirmed trisomy 21, with a false positive rate of 5.9%. Although majority (86.4%) were willing to have invasive testing, only few (3 or 17.6%) of the high risk group had testing. CONCLUSION: The study demonstrated that NT scan is feasible as a screening tool in pregnancy in Nigeria. Measures of improving utilization include wider dissemination of information, provision of dedicated NT clinics and manpower training. |
| File Format | HTM / HTML |
| e-ISSN | 19378688 |
| DOI | 10.11604/pamj.2014.18.62.3291 |
| Journal | Pan African Medical Journal |
| Volume Number | 18 |
| Language | English |
| Publisher | African Field Epidemiology Network |
| Publisher Date | 2014-01-01 |
| Publisher Place | Uganda |
| Access Restriction | Open |
| Subject Keyword | Discipline Medicine Down Syndrome Diagnosis Nuchal Translucency Measurement Prenatal Diagnosis False Positive Reactions Feasibility Studies Gestational Age Maternal Age Nigeria Pregnancy Pregnancy Trimester, First Prospective Studies Questionnaires Observational Study |
| Content Type | Text |
| Resource Type | Article |
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