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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Shanchun Liu, Xin Yu, Yunxian Hong, Xiumei Christoffel, Katherine K. Wang, Binyan Tsai, Hui-Ju Li, Zhiping Liu, Xue Tang, Genfu Xing, Houxun Brickman, Wendy J. Zimmerman, Donald Xu, Xiping Wang, Xiaobin |
| Spatial Coverage | China |
| Description | Country affiliation: United States Author Affiliation: Zhang S ( Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children's Memorial Hospital and Children's Memorial Research Center, Chicago, Illinois, USA.) |
| Abstract | The increasing prevalence of metabolic syndrome (MS) poses a serious public-health problem worldwide. Effective prevention and intervention require improved understanding of the factors that contribute to MS. We analyzed data on a large twin cohort to estimate genetic and environmental contributions to MS and to major MS components and their intercorrelations: waist circumference (WC), systolic (SBP) and diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglycerides (TGs), and high-density lipoprotein-cholesterol (HDL-C). We applied structural equation modeling to determine genetic and environmental structure of MS and its major components, using 1,617 adult female twin pairs recruited from rural China. The heritability estimate for MS was 0.42 (95% confidence interval (CI): 0.00-0.83) in this sample with low MS prevalence (4.4%). For MS components, heritability estimates were statistically significant and ranged from 0.13 to 0.64 highest for WC, followed by TG, SBP, DBP, HDL-C, and FPG. HDL-C was mainly influenced by common environmental factors (0.62, 95% CI: 0.58-0.62), whereas the other five MS components were largely influenced by unique environmental factors (0.32-0.44). Bivariate Cholesky decomposition analysis indicated that the clinical clustering of MS components may be explained by shared genetic and/or environmental factors. Our study underscores the importance of examining MS components as intercorrelated traits, and to carefully consider environmental and genetic factors in studying MS etiology. |
| File Format | HTM / HTML |
| ISSN | 19307381 |
| e-ISSN | 1930739X |
| DOI | 10.1038/oby.2009.125 |
| Journal | Obesity |
| Issue Number | 8 |
| Volume Number | 17 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Endocrinology Genetic Predisposition To Disease Metabolic Syndrome X Genetics Blood Pressure Cholesterol, Hdl Metabolism Diseases In Twins Etiology Phenotype Systole Triglycerides Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Twin Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology |
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