NDLI: INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Talbert, Matthew E. Langefeld, Carl D. Ziegler, Julie T. Haffner, Steven M. Norris, Jill M. Bowden, Donald W.
Description	Country affiliation: United States Author Affiliation: Talbert ME ( Program in Molecular Medicine and Translational Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.)
Abstract	The genome-wide association study by Herbert et al. identified the INSIG2 single-nucleotide polymorphism (SNP) rs7566605 as contributing to increased BMI in ethnically distinct cohorts. The present study sought to further clarify the matter, by testing whether SNPs of INSIG2 influenced quantitative adiposity or glucose homeostasis traits in Hispanics of the Insulin Resistance Atherosclerosis Family Study (IRASFS). Using a tagging SNP approach, rs7566605 and 31 additional SNPs were genotyped in 1,425 IRASFS Hispanics. SNPs were tested for association with six adiposity measures: BMI, waist circumference (WAIST), waist-to-hip ratio (WHR), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and VAT to SAT ratio (VSR). SNPs were also tested for association with fasting glucose (GFAST), fasting insulin (FINS), and three measures obtained from the frequently sampled intravenous glucose tolerance test: insulin sensitivity (S(I)), acute insulin response (AIR), and disposition index (DI). Most prominent association was observed with direct computed tomography (CT)-measured adiposity phenotypes, including VAT, SAT, and VSR (P values range from 0.007 to 0.044 for rs17586756, rs17047718, rs17047731, rs9308762, rs12623648, and rs11673900). Multiple SNP associations were observed with all glucose homeostasis traits (P values range from 0.001 to 0.031 for rs17047718, rs17047731, rs2161829, rs10490625, rs889904, and rs12623648). Using BMI as a covariate in evaluation of glucose homeostasis traits slightly reduced their association. However, association with adiposity and glucose homeostasis phenotypes is not significant following multiple comparisons adjustment. Trending association after multiple comparisons adjustment remains suggestive of a role for genetic variation of INSIG2 in obesity, but these results require validation.
File Format	HTM / HTML
ISSN	19307381
e-ISSN	1930739X
DOI	10.1038/oby.2009.94
Journal	Obesity
Issue Number	8
Volume Number	17
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Glucose Metabolism Intracellular Signaling Peptides And Proteins Genetics Membrane Proteins Obesity Polymorphism, Single Nucleotide Adiposity Body Mass Index Family Health Genetic Predisposition To Disease Hispanic Americans Homeostasis Insulin Ethnology Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology

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INSIG2 SNPS ASSOCIATED WITH OBESITY & GLUCOSE HOMEOSTASIS TRAITS IN HISPANICS: THE IRAS FAMILY STUDY

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