NDLI: Intra-abdominal adipose tissue is independently associated with sex-hormone binding globulin in premenopausal women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Azrad, Maria Gower, Barbara A. Hunter, Gary R. Nagy, Tim R.
Description	Country affiliation: United States Author Affiliation: Azrad M ( Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.)
Abstract	Lower serum concentrations of sex-hormone binding globulin (SHBG) are associated with increased risk for several obesity-related diseases in women including hormone-sensitive cancers, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Previous investigations have reported that body composition, specifically central obesity, and/or higher insulin concentrations are key factors associated with lower SHBG in overweight and obese women; however, these studies were limited by their cross-sectional design. We hypothesized that intra-abdominal adipose tissue (IAAT), a fat depot linked with an abnormal metabolic profile, is inversely and independently associated with SHBG. Therefore, we determined the longitudinal associations among SHBG, insulin, and IAAT in 107 premenopausal women enrolled in a weight loss study. Overweight (BMI 27-30 kg/m(2)) women were weight reduced until BMI of ≤ 24 was achieved. Body composition and IAAT were measured at baseline and after weight loss with dual-energy X-ray absorptiometry and computed tomography, respectively. Serum concentrations of insulin and SHBG were determined. Paired t-test showed that insulin and IAAT decreased significantly and SHBG increased significantly following weight loss (P < 0.0001 for all). Simple correlations from baseline showed no association with insulin and SHBG (r = -0.142, P = 0.143) and a significant inverse association between IAAT and SHBG (r = -0.43, P < 0.0001). Repeated measures mixed-model showed that after adjusting for age and time (weight loss), IAAT was significantly inversely associated with SHBG (P = 0.0002) and there was no association with insulin and SHBG (P = 0.180). We conclude that SHBG concentrations are influenced by IAAT and not insulin in premenopausal women.
File Format	HTM / HTML
ISSN	19307381
e-ISSN	1930739X
DOI	10.1038/oby.2011.375
Journal	Obesity
Issue Number	5
Volume Number	20
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Diabetes Mellitus, Type 2 Metabolism Intra-abdominal Fat Metabolic Syndrome X Obesity Premenopause Sex Hormone-binding Globulin Absorptiometry, Photon Biological Markers Body Mass Index Cross-sectional Studies Physiopathology Prevention & Control Longitudinal Studies Risk Factors Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology

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