NDLI: Effects of FTO genotype on weight loss and metabolic risk factors in response to calorie restriction among Japanese women.

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Effects of FTO genotype on weight loss and metabolic risk factors in response to calorie restriction among Japanese women.

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Effects of FTO genotype on weight loss and metabolic risk factors in response to calorie restriction among Japanese women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Matsuo, Tomoaki Nakata, Yoshio Murotake, Yukako Hotta, Kikuko Tanaka, Kiyoji
Description	Country affiliation: Japan Author Affiliation: Matsuo T ( Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan. matsuo1411@ybb.ne.jp)
Abstract	Effects of gene variants in the fat-mass and obesity-associated (FTO) gene (primarily rs9939609) on weight loss induced by lifestyle intervention are controversial. The aim of this study was to investigate whether FTO gene variations are associated with weight-reduction and changes in metabolic risk factors in response to a 14-week calorie restriction. In total, 204 Japanese women (aged 24-66 years; BMI ≥ 25 kg/m(2)) enrolled as subjects and attended dietary lectures instructing them on how to consume a nutritionally balanced diet of 1,200 kcal/day. Fat mass, both at baseline (P = 0.100) and after the intervention (P = 0.020), was higher in subjects with the AA genotype (n = 15; 7.3%) than in those with TT (n = 114; 55.9%) and TA (n = 75; 36.8%) genotypes. The change in fat-mass tended to be smaller in subjects with the AA genotype than in those with other genotypes (P = 0.065). However, the subjects with the risk allele could still decrease their body weight and improve metabolic risk factors significantly. Our data suggest that the impact of FTO rs9939609 in Japanese women may not be great enough to change body weight or metabolic risk factors in response to calorie restriction. Environmental and behavioral factors may overcome the effects of genes on weight reduction.
File Format	HTM / HTML
ISSN	19307381
Issue Number	5
Volume Number	20
e-ISSN	1930739X
Journal	Obesity
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Caloric Restriction Methods Obesity Genetics Proteins Adult Aged Asian Continental Ancestry Group Female Genetic Predisposition To Disease Genetic Variation Genotype Humans Middle Aged Diet Therapy Risk Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology

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