NDLI: The subthalamic nucleus is a key-structure of limbic basal ganglia functions.

Please wait, while we are loading the content...

Intensified testing for attention-deficit hyperactivity disorder (ADHD) in girls should reduce depression and smoking in adult females and the prevalence of ADHD in the longterm.

Erythropoietin as a novel therapeutic agent for atrophic age-related macular degeneration.

Gas bubbles may not be the underlying cause of decompression illness - The at-depth endothelial dysfunction hypothesis.

Combination sonodynamic therapy with immunoadjuvant may be a promising new modality for cancer treatment.

Intralesional injection of Pingyangmycin may be an effective treatment for epulis.

Chronic organophosphate (OP)-induced neuropsychiatric disorder is a withdrawal syndrome.

Neurogenic hypothesis of cardiac ischemic pain.

Cognitive appraisals and physical health in people with posttraumatic stress disorder (PTSD).

Pretreatment with alternate day modified fast will permit higher dose and frequency of cancer chemotherapy and better cure rates.

Carbonic anhydrase III: the new hope for the elimination of exercise-induced muscle fatigue.

Is cancer a genetic program with an unknown function?

Platelet-rich plasma - A promising cell carrier for micro-invasive articular cartilage repair.

Morphological adaptation of the nasal valve area to climate.

Supplementation with insulin and antioxidants could be advantageous in the treatment of vitiligo.

Abnormal ossification as a cause the progression of adolescent idiopathic scoliosis.

'Infectobesity: viral infections (especially with human adenovirus-36: Ad-36) may be a cause of obesity.

Low-magnitude mechanical vibration may be applied clinically to promote dental implant osseointegration.

Treatment of Parkinson's disease could be regulated by movement sensors: subcutaneous infusion of varying apomorphine doses according to the intensity of motor activity.

Cathepsin K/TRAP: Can they be used to induce osteogenesis?

The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis.

Complementary thoughts on the future of internet science: Can digital libraries avoid scientific tunnel-vision and lead to innovation?

Controlled application and scheduled removal of nanoparticle based chemotherapeutics (CARL) will reduce dose limiting adverse events in anticancer chemotherapy.

Tocilizumab as a potential treatment in Schnitzler syndrome.

Increased UVA exposures and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma.

The subthalamic nucleus is a key-structure of limbic basal ganglia functions.

AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues.

Kraepelin-fraud syndrome.

Year: 2009 Volume: 72 Issue: 3

Year: 2009 Volume: 72 Issue: 2

Year: 2009 Volume: 72 Issue: 1

Year: 2008 Volume: 71

Year: 2008 Volume: 70

Year: 2007 Volume: 69

Year: 2007 Volume: 68

Year: 2006 Volume: 66

The subthalamic nucleus is a key-structure of limbic basal ganglia functions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Haegelen, Claire Rouaud, Tiphaine Darnault, Pierre Morandi, Xavier
Description	Country affiliation: France Author Affiliation: Haegelen C ( Department of Neurosurgery, CHRU Pontchaillou, Rue Henri Le Guilloux, 35033 Rennes, Cedex 2, France. Claire.HAEGELEN@chu-rennes.fr)
Abstract	Among the basal ganglia nuclei, the subthalamic nucleus has a major function in the motor cortico-basal ganglia-thalamo-cortical circuit and is a target site for neurosurgical treatment such as parkinsonian patients with long-term motor fluctuations and dyskinesia. According to animal and human studies, the motor functions of the subthalamic nucleus have been well documented whereas its implication on limbic functions is still less well understood and is only partially explained by anatomical and functional theories of basal ganglia organisation. After chronic subthalamic nucleus stimulation in patients with Parkinson's disease, many studies showed executive impairments, apathy, depression, hypomania, and impairment of recognition of negative facial emotions. The medial tip of the subthalamic nucleus represents its limbic part. This part receives inputs from the anterior cingulate cortex, the medial prefrontal cortex, the limbic part of the striatum (nucleus accumbens), the ventral tegmental area and the limbic ventral pallidum. The medial tip of the subthalamic nucleus projects to the limbic part of the substantia nigra and the ventral tegmental area. We propose a new function scheme of the limbic system, establishing connections between limbic cortical structures (medial prefrontal cortex, amygdala and hippocampus) and the limbic part of the basal ganglia. This new circuit could be composed of a minor part based on the model of cortico-basal ganglia-thalamo-cortical loop, and of a major part linking the subthalamic nucleus with the mesolimbic dopaminergic pathway via the ventral tegmental area and the nucleus accumbens, and with limbic cortical structures. This scheme could explain limbic impairments after subthalamic nucleus stimulation by disruption of limbic information inside the subthalamic nucleus and the ventral tegmental area.
File Format	HTM / HTML
ISSN	03069877
Issue Number	4
Journal	Medical Hypotheses
Volume Number	72
e-ISSN	15322777
Language	English
Publisher	Elsevier
Publisher Date	2009-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medical theory Basal Ganglia Physiology Subthalamic Nucleus Deep Brain Stimulation Humans Parkinson Disease Physiopathology Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Surgical management of Parkinson's disease.

Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output.

Improving outcomes of subthalamic nucleus deep brain stimulation in Parkinson's disease.

What neurophysiological recordings tell us about cognitive and behavioral functions of the human subthalamic nucleus.

Stimulation sites in the subthalamic nucleus projected onto a mean 3-D atlas of the thalamus and basal ganglia.

Deep Brain Stimulation of the Subthalamic Nucleus Enhances Emotional Processing in Parkinson Disease

Influence of deep brain stimulation of the subthalamic nucleus on cognitive function in patients with Parkinson's disease.

Alpha frequency modulation in the human basal ganglia is dependent on motor task.

Subthalamic deep brain stimulation restores automatic response activation and increases susceptibility to impulsive behavior in patients with Parkinson's disease.

The subthalamic nucleus is a key-structure of limbic basal ganglia functions.

Similar Documents

Surgical management of Parkinson's disease.

Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output.

Improving outcomes of subthalamic nucleus deep brain stimulation in Parkinson's disease.

What neurophysiological recordings tell us about cognitive and behavioral functions of the human subthalamic nucleus.

Stimulation sites in the subthalamic nucleus projected onto a mean 3-D atlas of the thalamus and basal ganglia.

Deep Brain Stimulation of the Subthalamic Nucleus Enhances Emotional Processing in Parkinson Disease

Influence of deep brain stimulation of the subthalamic nucleus on cognitive function in patients with Parkinson's disease.

Alpha frequency modulation in the human basal ganglia is dependent on motor task.

Subthalamic deep brain stimulation restores automatic response activation and increases susceptibility to impulsive behavior in patients with Parkinson's disease.

The subthalamic nucleus is a key-structure of limbic basal ganglia functions.