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Do neurotrophins regulate the feto-placental development?

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Do neurotrophins regulate the feto-placental development?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mayeur, Sylvain Lukaszewski, Marie Amélie Breton, Christophe Storme, Laurent Vieau, Didier Lesage, Jean
Description	Country affiliation: France Author Affiliation: Mayeur S ( Université Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Equipe dénutritions maternelles périnatales, Université de Lille1, Bâtiment SN4, F-59655 Villeneuve d'Ascq, France.)
Abstract	Numerous data highlight the importance of a fine regulation of the fetal growth for the individual's subsequent susceptibility to diseases. Recent evidence suggests that neurotrophins may have important functions during pregnancy and that they could modulate fetal growth. We hypothesize that neurotrophins may participate in fetal growth by different pathways: (1) these molecules may participate in the development and the maturation of both central and peripheral fetal organs, including the placenta; (2) neurotrophins may constitute a link between the maternal nutrition and the fetal nutrients demand and thus could act as a nutrient sensor for the development and efficiency of the placenta; (3) maternal and placental neurotrophins may control the fetal development directly but also by activating the production and release of others growth factors. In conclusion, neurotrophins may participate to a new pathway controlling fetal growth and may be implicated, at least in part, under physiopathological conditions in disturbances of the fetal growth trajectory.
File Format	HTM / HTML
ISSN	03069877
Issue Number	5
Volume Number	76
e-ISSN	15322777
Journal	Medical Hypotheses
Language	English
Publisher	Elsevier
Publisher Date	2011-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medical theory Fetal Development Physiology Nerve Growth Factors Metabolism Placentation Amniotic Fluid Animals Female Homeostasis Humans Intercellular Signaling Peptides And Proteins Mice Models, Biological Models, Theoretical Placenta Pregnancy Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine

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Do neurotrophins regulate the feto-placental development?