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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fan, L. Wang, Tian-Long Xu, Y. C. Ma, Y. H. Ye, W. G. |
| Description | Country affiliation: China Author Affiliation: Fan L ( Department of Anaesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.) |
| Abstract | Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimer's disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and pathophysiological mechanisms of this surgical complication remain elusive. Therefore, developing strategies for preventing or treating POCD is still challenging. However, increasing evidence suggests that central and systemic inflammation triggered by surgery likely plays a fundamental role in POCD developing and progression. Minocycline, a tetracycline derivative with anti-inflammatory properties, has been shown to be effective in treating neuroinflammatory related conditions or neurodegenerative diseases such as AD, Parkinson's disease, Huntington's disease. Considering that inflammation may be a potential factor of POCD and minocycline is effective in improving cognitive dysfunction induced by inflammation, we hypothesize that minocycline may be useful to treat/prevent the POCD development after surgery in elderly patients. |
| File Format | HTM / HTML |
| ISSN | 03069877 |
| Issue Number | 5 |
| Volume Number | 76 |
| e-ISSN | 15322777 |
| Journal | Medical Hypotheses |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medical theory Cognition Disorders Drug Therapy Minocycline Pharmacology Postoperative Complications Prevention & Control Aged Anti-bacterial Agents Anti-inflammatory Agents Brain Diseases Pathology Humans Inflammation Models, Theoretical Neurodegenerative Diseases Sepsis Tetracycline Treatment Outcome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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