NDLI: An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kuo, Tzong-fu Lee, Sheng-Yang Wu, Hong-Da Poma, Malosi Wu, Yu-Wei Yang, Jen-Chang
Description	Author Affiliation: Kuo TF ( Department of Veterinary Medicine, National Taiwan University, Taipei 110, Taiwan, ROC); Lee SY ( School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC); Wu HD ( School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC.); Poma M ( School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC.); Wu YW ( Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 110, Taiwan, ROC.); Yang JC ( Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 110, Taiwan, ROC)
Abstract	The purpose of this in vivo study was to evaluate the effect of human dental pulp stem cells (hDPSCs) on various resorbable calcium sulfate/calcium phosphate bone grafts in bone regeneration. Granular particles of calcium sulfate dehydrate (CSD), -calcium sulfate hemihydrate/amorphous calcium phosphate ( -CSH/ACP), and CSD/ß-tricalcium phosphates (ß-TCP) were prepared for in vitro dissolution and implantation test. The chemical compositions of specimen residues after dissolution test were characterized by XRD. The ratios of new bone formation for implanted grafts/hDPSCs were evaluated using mandible bony defect model of Lanyu pig. All the graft systems exhibited a similar two-stage dissolution behavior and phase transformation of poor crystalline HAp. Eight weeks post-operation, the addition of hDPSCs to various graft systems showed statistically significant increasing in the ratio of new bone formation (p<0.05). Null hypothesis of hDPSCs showing no scaffold dependence in bone regeneration was rejected. The results suggest that the addition of hDPSCs to calcium sulfate based xenografts could enhance the bone regeneration in the bony defect.
File Format	HTM / HTML
ISSN	09284931
Volume Number	50
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2015-05-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Bone Transplantation Calcium Sulfate Pharmacology Dental Pulp Cytology Stem Cell Transplantation Stem Cells Transplantation, Heterologous Animals Calcium Phosphates Humans Microscopy, Electron, Scanning Osteogenesis Drug Effects Sus Scrofa X-ray Diffraction Journal Article
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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