NDLI: Genipin-modified gelatin nanocarriers as swelling controlled drug delivery system for in vitro release of cytarabine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Khan, Huda Shukla, R. N. Bajpai, A. K.
Description	Country affiliation: India Author Affiliation: Khan H ( Department of Chemistry, S.A.T.I., Vidhisha, Madhya Pradesh, India.); Shukla RN ( Department of Chemistry, S.A.T.I., Vidhisha, Madhya Pradesh, India.); Bajpai AK ( Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, Madhya Pradesh, India. Electronic address: akbmrl@yahoo.co.in.)
Abstract	The aim of the present investigation was to design biocompatible gelatin nanoparticles, capable of releasing the cytarabine drug in a controllable way by regulating the extent of swelling of nanoparticles. In order to achieve the proposed objectives, gelatin (Type A, derived from acid cured tissue) was modified by crosslinking with genipin and nanoparticles of crosslinked gelatin were prepared using single water in oil (W/O) emulsion technique. The nanoparticles were characterized by techniques like FTIR, SEM, TEM, particles size analysis, and surface potential measurements. The nanoparticle chemical architecture was found to influence drug-releasing capacity. The influence of experimental conditions such as pH and simulated physiological fluids as the release medium was also investigated on the release profiles of cytarabine. It is possible to fabricate high-performance materials, by designing of controlled size gelatin nanoparticles with good biocompatible properties along with desired drug release profiles.
File Format	HTM / HTML
ISSN	09284931
Volume Number	61
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2016-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Antimetabolites, Antineoplastic Chemistry Cytarabine Drug Carriers Gelatin Iridoids Nanoparticles Metabolism Drug Liberation Hydrogen-ion Concentration Ultrastructure Particle Size Spectroscopy, Fourier Transform Infrared Journal Article
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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