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Reduction of blood lead levels in lead-exposed mice by dietary supplements and natural antioxidants.

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Year: 2011 Volume: 91 Issue: 2

Year: 2011 Volume: 91 Issue: 1

Year: 2010 Volume: 90

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Reduction of blood lead levels in lead-exposed mice by dietary supplements and natural antioxidants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jiao, Jingjing Lü, Guishan Liu, Xiaojie Zhu, Hui Zhang, Yu
Description	Country affiliation: United States Author Affiliation: Jiao J ( Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.)
Abstract	BACKGROUND: Lead exposure is a global environmental problem that induces lifelong adverse health effects. Our aim was to investigate the effect of dietary supplements and natural antioxidants on blood lead levels (BLL) in lead-exposed mice, and observe their impact on the absorption of calcium, iron and zinc in vivo. RESULTS: All of selected dietary supplements (calcium lactate, zinc sulfate, ferrous sulfate, ascorbic acid and calcium-rich milk) and natural antioxidants (extract of Chinese wolfberry, extract of Hangzhou white chrysanthemum and antioxidant extract of bamboo leaves) have promising capacity of reducing BLL in lead-exposed mice with an reduction range from 56.2% to 65.1%. The metal ion-mediated chelating and competitively inhibitory mechanisms may elucidate their reduction effect. Besides, blood calcium, iron and zinc levels were not significantly changed in all of the experimental groups, indicating that the intake of all additives does not disturb the absorption of essential mineral elements in mice. CONCLUSION: All the studied additives not only effectively reduce BLL, but also maintain normal calcium, iron and zinc absorption in mice. The formulation of calcium, iron and zinc supplements and/or polyphenol and vitamin-rich antioxidants may constitute an important secondary prevention effort to reduce BLL and lead exposure.
File Format	HTM / HTML
ISSN	00225142
Issue Number	3
Volume Number	91
e-ISSN	10970010
Journal	Journal of the Science of Food and Agriculture
Language	English
Publisher	Wiley
Publisher Date	2011-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Agriculture Antioxidants Pharmacology Dietary Supplements Drugs, Chinese Herbal Therapeutic Use Lead Poisoning Drug Therapy Lead Blood Micronutrients Phytotherapy Animals Ascorbic Acid Calcium, Dietary Iron, Dietary Male Mice Mice, Inbred Icr Plants, Medicinal Zinc Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Food Science Biotechnology Agronomy and Crop Science

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