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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wilborn, Colin D. Taylor, Lemuel W. Greenwood, Michael Kreider, Richard B. Willoughby, Darryn S. |
| Description | Country affiliation: United States Author Affiliation: Wilborn CD ( Department of Exercise Sport Science, University of Mary Hardin Baylor, Belton, Texas, USA.) |
| Abstract | A single bout of high-intensity resistance exercise is capable of activating the expression of various genes in skeletal muscle involved in hypertrophy such as myosin heavy chain (MHC) isoforms, myogenic regulatory factors (MRFs), and growth factors. However, the specific role exercise intensity plays on the expression of these genes is not well defined. The purpose of this study was to investigate the effects of exercise intensity on MHC (type I, IIA, IIX), MRF (Myo-D, myogenin, MRF-4, myf5), and growth factor (insulin-like growth factor [IGF]-1, IGF-1 receptor [IGF-R1], mechano-growth factor [MGF]) mRNA expression. Thirteen male participants (21.5 +/- 2.9 years, 86.1 +/- 19.5 kg, 69.7 +/- 2.7 in.) completed bouts of resistance exercise involving 4 sets of 18-20 repetitions with 60-65% 1 repetition maximum (1RM) and 4 sets of 8-10 repetitions with 80-85% 1RM. Vastus lateralis biopsies were obtained immediately before exercise, and at 30 minutes, 2 hours, and 6 hours after each bout. The levels of mRNA expression were determined using real-time polymerase chain reaction. Data were analyzed using 2 x 4 multivariate analysis of variance (p |
| File Format | HTM / HTML |
| ISSN | 10648011 |
| Issue Number | 8 |
| Volume Number | 23 |
| e-ISSN | 15334287 |
| Journal | Journal of Strength and Conditioning Research |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2009-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Sport Sciences Biological Markers Metabolism Muscle Development Physiology Muscle, Skeletal Rna, Messenger Resistance Training Methods Analysis Of Variance Biopsy Cross-over Studies Humans Intercellular Signaling Peptides And Proteins Genetics Male Myogenic Regulatory Factors Myosin Heavy Chains Myostatin Reverse Transcriptase Polymerase Chain Reaction Time Factors Up-regulation Young Adult Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science |
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