NDLI: Neuroprotective and neurorestorative effects of thymosin ß4 treatment initiated 6 hours after traumatic brain injury in rats.

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Neuroprotective and neurorestorative effects of thymosin ß4 treatment initiated 6 hours after traumatic brain injury in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xiong, Ye Zhang, Yanlu Mahmood, Asim Meng, Yuling Zhang, Zheng Gang Morris, Daniel C. Chopp, Michael
Description	Country affiliation: United States Author Affiliation: Xiong Y ( Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA. yxiong1@hfhs.org)
Abstract	OBJECT: Thymosin ß4 (Tß4) is a regenerative multifunctional peptide. The aim of this study was to test the hypothesis that Tß4 treatment initiated 6 hours postinjury reduces brain damage and improves functional recovery in rats subjected to traumatic brain injury (TBI). METHODS: Traumatic brain injury was induced by controlled cortical impact over the left parietal cortex in young adult male Wistar rats. The rats were randomly divided into the following groups: 1) saline group (n = 7); 2) 6 mg/kg Tß4 group (n = 8); and 3) 30 mg/kg Tß4 group (n = 8). Thymosin ß4 or saline was administered intraperitoneally starting at 6 hours postinjury and again at 24 and 48 hours. An additional group of 6 animals underwent surgery without TBI (sham-injury group). Sensorimotor function and spatial learning were assessed using the modified Neurological Severity Score and the Morris water maze test, respectively. Animals were euthanized 35 days after injury, and brain sections were processed to assess lesion volume, hippocampal cell loss, cell proliferation, and neurogenesis after Tß4 treatment. RESULTS: Compared with saline administration, Tß4 treatment initiated 6 hours postinjury significantly improved sensorimotor functional recovery and spatial learning, reduced cortical lesion volume and hippocampal cell loss, and enhanced cell proliferation and neurogenesis in the injured hippocampus. The high dose of Tß4 showed better beneficial effects compared with the low-dose treatment. CONCLUSIONS: Thymosin ß4 treatment initiated 6 hours postinjury provides both neuroprotection and neurorestoration after TBI, indicating that Tß4 has promising therapeutic potential in patients with TBI. These data warrant further investigation of the optimal dose and therapeutic window of Tß4 treatment for TBI and the associated underlying mechanisms.
File Format	HTM / HTML
ISSN	00223085
e-ISSN	19330693
DOI	10.3171/2012.1.JNS111729
Journal	Journal of Neurosurgery
Issue Number	5
Volume Number	116
Language	English
Publisher	American Association of Neurological Surgeons
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurosurgery Brain Injuries Drug Therapy Neuroprotective Agents Thymosin Pharmacology Animals Pathology Cell Count Cerebral Cortex Dentate Gyrus Fluorescent Antibody Technique Hippocampus Immunohistochemistry Maze Learning Drug Effects Physiology Neovascularization, Physiologic Neurogenesis Rats, Wistar Recovery Of Function Therapeutic Use Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Surgery

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