| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Kistowska, Magdalena Gehrke, Samuel Jankovic, Dragana Kerl, Katrin Fettelschoss, Antonia Feldmeyer, Laurence Fenini, Gabriele Kolios, Antonios Navarini, Alexander Ganceviciene, Ruta Schauber, Jürgen Contassot, Emmanuel French, Lars E. |
| Description |
Country affiliation: Switzerland Author Affiliation: Kistowska M ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Gehrke S ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Jankovic D ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Kerl K ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Fettelschoss A ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Feldmeyer L ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Fenini G ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Kolios A ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Navarini A ( Department of Dermatology, University Hospital, Zürich, Switzerland.); Ganceviciene R ( Centre of Dermatovenereology, Vilnius University Hospital, Vilnius, Lithuania.); Schauber J ( Department of Dermatology and Allergy, Ludwig-Maximilian University, Munich, Germany.); Contassot E ( Department of Dermatology, University Hospital, Zürich, Switzerland.); French LE ( Department of Dermatology, University Hospital, Zürich, Switzerland.) |
| Abstract |
Acne vulgaris is potentially a severe skin disease associated with colonization of the pilo-sebaceous unit by the commensal bacterium Propionibacterium acnes and inflammation. P. acnes is considered to contribute to inflammation in acne, but the pathways involved are unclear. Here we reveal a mechanism that regulates inflammatory responses to P. acnes. We show that IL-1ß mRNA and the active processed form of IL-1ß are abundant in inflammatory acne lesions. Moreover, we identify P. acnes as a trigger of monocyte-macrophage NLRP3-inflammasome activation, IL-1ß processing and secretion that is dependent on phagocytosis, lysosomal destabilization, reactive oxygen species, and cellular K+ efflux. In mice, inflammation induced by P. acnes is critically dependent on IL-1ß and the NLRP3 inflammasome of myeloid cells. These findings show that the commensal P. acnes-by activating the inflammasome-can trigger an innate immune response in the skin, thus establishing the NLRP3-inflammasome and IL-1ß as possible therapeutic targets in acne. |
| File Format |
HTM / HTML |
| ISSN |
0022202X |
| e-ISSN |
15231747 |
| Journal |
Journal of Investigative Dermatology |
| Issue Number |
3 |
| Volume Number |
134 |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-03-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Dermatology Acne Vulgaris Immunology Gram-positive Bacterial Infections Interleukin-1beta Monocytes Microbiology Propionibacterium Acnes Metabolism Animals Carrier Proteins Cell Line, Tumor Disease Models, Animal Inflammasomes Genetics Keratinocytes Cytology Leukemia Mice Mice, Inbred C57bl Mice, Knockout Phagocytosis Rna, Small Interfering Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Cell Biology Biochemistry Molecular Biology Dermatology |
