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Anti-psoriatic therapy recovers high-density lipoprotein composition and function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Holzer, Michael Wolf, Peter Inzinger, Martin Trieb, Markus Curcic, Sanja Pasterk, Lisa Weger, Wolfgang Heinemann, Akos Marsche, Gunther
Description	Country affiliation: Austria Author Affiliation: Holzer M ( Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.); Wolf P ( Department of Dermatology, Medical University of Graz, Graz, Austria.); Inzinger M ( Department of Dermatology, Medical University of Graz, Graz, Austria.); Trieb M ( Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.); Curcic S ( Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.); Pasterk L ( Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.); Weger W ( Department of Dermatology, Medical University of Graz, Graz, Austria.); Heinemann A ( Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.); Marsche G ( Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.)
Abstract	Psoriasis is a chronic inflammatory disorder associated with increased cardiovascular mortality. Psoriasis affects high-density lipoprotein (HDL) composition, generating dysfunctional HDL particles. However, data regarding the impact of anti-psoriatic therapy on HDL composition and function are not available. HDL was isolated from 15 psoriatic patients at baseline and after effective topical and/or systemic anti-psoriatic therapy and from 15 age- and sex-matched healthy controls. HDL from psoriatic patients showed a significantly impaired capability to mobilize cholesterol from macrophages (6.4 vs. 8.0% [(3)H]cholesterol efflux, P<0.001), low paraoxonase (217 vs. 350 µM(-1) minute(-1) mg(-1) protein, P=0.011) and increased Lp-PLA2 activities (19.9 vs. 12.1 nM(-1) minute(-1) mg(-1) protein, P=0.028). Of particular interest, the anti-psoriatic therapy significantly improved serum lecithin-cholesterol acyltransferase activity and decreased total serum lipolytic activity but did not affect serum levels of HDL-cholesterol. Most importantly, these changes were associated with a significantly improved HDL-cholesterol efflux capability. Our results provide evidence that effective anti-psoriatic therapy recovers HDL composition and function, independent of serum HDL-cholesterol levels, and support to the emerging concept that HDL function may be a better marker of cardiovascular risk than HDL-cholesterol levels.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
DOI	10.1038/jid.2013.359
Journal	Journal of Investigative Dermatology
Issue Number	3
Volume Number	134
Language	English
Publisher	Elsevier
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Lipoproteins, Hdl Blood Macrophages Metabolism Puva Therapy Psoriasis Drug Therapy Administration, Topical Antigens, Human Platelet Aryldialkylphosphatase Cardiovascular Diseases Mortality Cholesterol Pharmacokinetics Lipolysis Drug Effects Physiology Phosphatidylcholine-sterol O-acyltransferase Immunology Risk Factors Tritium Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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Anti-psoriatic therapy recovers high-density lipoprotein composition and function.

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