NDLI: Peripheral and local human papillomavirus 16-specific CD8+ T-cell expansions characterize erosive oral lichen planus.

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Peripheral and local human papillomavirus 16-specific CD8+ T-cell expansions characterize erosive oral lichen planus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Viguier, Manuelle Bachelez, Hervé Poirier, Béatrice Kagan, Jérémy Battistella, Maxime Aubin, François Touzé, Antoine Carmagnat, Maryvonnick Francès, Camille Gougeon, Marie-Lise Fazilleau, Nicolas
Description	Country affiliation: France Author Affiliation: Viguier M ( 1] Antiviral Immunity Biotherapy and Vaccine Unit, Institut Pasteur, Paris, France [2] Sorbonne Paris Cité Université Paris Diderot, Paris, France.); Bachelez H ( 1] Sorbonne Paris Cité Université Paris Diderot, Paris, France [2] Université Paris Descartes, Imagine Institute, Necker Hospital, Paris, France.); Poirier B ( Antiviral Immunity Biotherapy and Vaccine Unit, Institut Pasteur, Paris, France.); Kagan J ( 1] Centre de Physiopathologie de Toulouse Purpan, Toulouse, France [2] INSERM, U1043, Toulouse, France [3] CNRS, UMR5282, Toulouse, France [4] Université Toulouse III Paul-Sabatier, Toulouse, France.); Battistella M ( 1] Antiviral Immunity Biotherapy and Vaccine Unit, Institut Pasteur, Paris, France [2] Université Paris Diderot, UMR-S728, INSERM, Paris, France.); Aubin F ( Service de Dermatologie, Centre Hospitalier Universitaire, SFR FED 4234, EA 3181, Université de Franche Comté, Besançon, France.); Touzé A ( UMR 1282 INRA-Université François Rabelais, Tours, France.); Carmagnat M ( Laboratoire d'Immunologie, Hôpital Saint-Louis, Paris, France.); Francès C ( Service de Dermatologie-Allergologie, Hôpital Tenon, Université Paris VI, AP-HP, Paris, France.); Gougeon ML ( Antiviral Immunity Biotherapy and Vaccine Unit, Institut Pasteur, Paris, France.); Fazilleau N ( 1] Centre de Physiopathologie de Toulouse Purpan, Toulouse, France [2] INSERM, U1043, Toulouse, France [3] CNRS, UMR5282, Toulouse, France [4] Université Toulouse III Paul-Sabatier, Toulouse, France.)
Abstract	Erosive oral lichen planus (OLP) is a chronic, disabling mucocutaneous dysimmune rare disease characterized by mucosal inflammatory erosive lesions with pathological evidence for a marked CD8+ cytotoxic T-lymphocyte (CTL) infiltration. However, the specificity of lesional CTL in OLP has never been analyzed. To investigate the molecular mechanisms underlying dysregulation of T-cell immune responses in patients with OLP, we studied the diversity and antigen specificity of the TCR expressed by CD8+ T cells using dextramer staining, spectratyping, and TCR sequencing in 10 OLP patients undergoing extracorporeal photochemotherapy. Expansions of TCRVß3-bearing CD8+ T cells were found in peripheral blood and in lesional tissues of OLP patients. Spectratyping and sequencing studies identified specific clonotypes in each patient. These expansions were enriched with human papillomavirus 16 (HPV16)-specific CD8+ T cells in HLA-A*0201+ patients as shown by their immune recognition of the E711-20 immunodominant epitope. Under treatment with extracorporeal photochemotherapy, clonotypic CD8+ T-cell expansions decreased in parallel with clinical remission. Altogether, these data establish a link between HPV infection and OLP pathogenesis by identifying a massive clonal expansion of CD8+ T cells with increased frequency of HPV 16-specific CD8+ T cells in OLP patients.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
Journal	Journal of Investigative Dermatology
Issue Number	2
Volume Number	135
Language	English
Publisher	Elsevier
Publisher Date	2015-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Cd8-positive T-lymphocytes Immunology Human Papillomavirus 16 Lichen Planus, Oral Genes, T-cell Receptor Beta Virology Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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