NDLI: Inhibition of human melanoma growth by a non-cardioselective ß-blocker.

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Inhibition of human melanoma growth by a non-cardioselective ß-blocker.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wrobel, Ludovic J. Le Gal, Frederique Anne
Description	Country affiliation: Switzerland Author Affiliation: Wrobel LJ ( Department of Internal Medicine-Dermatology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.); Le Gal FA ( Department of Internal Medicine-Dermatology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.)
Abstract	Recently, retrospective studies provided conflicting results on the benefit of ß-adrenoceptor-blockers (ß-blockers) on melanoma progression. Most of these studies did not define the ß-blocker used, making it difficult to understand the source of discrepancies between results. Therefore, we investigated the effect of non-cardioselective and cardioselective ß-blockers on melanoma progression at the cellular, molecular, and tumor levels. Here we show that the non-cardioselective ß-blocker propranolol hydrochloride (propranolol) inhibits proliferation and induces apoptosis in primary cell cultures derived from a primary and a metastasis of human melanoma and in melanoma cell lines. In contrast, the cardioselective ß-blocker metoprolol tartrate hardly affects melanoma cell survival or proliferation. We further highlight that a daily treatment with propranolol slows down tumor development in immunodeficient mice transplanted with human melanoma cells. RNA microarrays, quantitative PCR, and histochemistry analyses showed that propranolol regulates the expression of different genes involved in tumor angiogenesis, cell death, or proliferation. Thus, our results suggest that non-cardioselective ß-blockers affect melanoma progression, and bring first clues about the pathways involved in this antitumor effect.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
Journal	Journal of Investigative Dermatology
Issue Number	2
Volume Number	135
Language	English
Publisher	Elsevier
Publisher Date	2015-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Adrenergic Beta-antagonists Pharmacology Melanoma Drug Therapy Apoptosis Drug Effects Cell Line, Tumor Cell Proliferation Pathology Metoprolol Neovascularization, Pathologic Prevention & Control Propranolol Transcriptome Xenograft Model Antitumor Assays Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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