NDLI: Resveratrol Regulates Activated Hepatic Stellate Cells by Modulating NF-κB and the PI3K/Akt Signaling Pathway.

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Resveratrol Regulates Activated Hepatic Stellate Cells by Modulating NF-κB and the PI3K/Akt Signaling Pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, De-Quan Sun, Peng Jin, Quan Li, Xia Zhang, Yu Zhang, Yu-Jing Wu, Yan-Ling Nan, Ji-Xing Lian, Li-Hua
Description	Country affiliation: China Author Affiliation: Zhang DQ ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.); Sun P ( Dept. of Pharmacy, Yanbian Univ. Hospital, Yanji, 133000, Jilin Province, China.); Jin Q ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.); Li X ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.); Zhang Y ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.); Zhang YJ ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.); Wu YL ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.); Nan JX ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.); Lian LH ( Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin Province, China.)
Abstract	In the present study, we investigated whether resveratrol could suppress the hepatic fibrogenesis in activated hepatic stellate cells. The immortalized rat hepatic stellate cells, t-HSC/Cl-6, were treated with resveratrol 1 h prior to lipopolysaccharide (LPS, 1 µg/mL). Resveratrol decreased t-HSC/Cl-6 cell viability at much lower concentrations within 24 h. Resveratrol pretreatment also decreased the LPS-induced protein expression of -SMA and collagen I. In addition, resveratrol significantly reduced the protein expression of Toll-like receptor 4 (TLR4) and myeloid differentiation primary response gene 88 (MyD88), and the expression of phosphorylated phosphatidylinositol 3-kinase (PI3K) and phosphorylated serine/threonine kinase B (Akt). Moreover, resveratrol markedly blocked the translocation of nuclear factor (NF)-κB in LPS-activated HSCs. Furthermore, resveratrol inhibited HSCs activation through stimulating LXRß, but did not influence LXR . Overall, we conclude that the antifibrotic effect of resveratrol is the result of blocking NF-κB activation and PI3K/Akt phosphorylation, which inhibits HSC activation to obstruct liver fibrosis. Thus, resveratrol may be a natural agent for preventing hepatic fibrosis.
File Format	HTM / HTML
ISSN	00221147
Issue Number	1
Volume Number	81
e-ISSN	17503841
Journal	Journal of Food Science
Language	English
Publisher	Wiley (on behalf ofInstitute of Food Technologists)
Publisher Date	2016-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Food science Hepatic Stellate Cells Drug Effects Liver Cirrhosis Metabolism Liver Nf-kappa B Phosphatidylinositol 3-kinase Protein-serine-threonine Kinases Stilbenes Pharmacology Actins Animals Cell Line Cell Survival Collagen Pathology Lipopolysaccharides Prevention & Control Myeloid Differentiation Factor 88 Phosphatidylinositol 3-kinases Phosphorylation Phytotherapy Plant Extracts Therapeutic Use Rats Signal Transduction Toll-like Receptor 4 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Food Science

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