NDLI: Expression of ErbB-1 and ErbB-2 in meningioma.

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Expression of ErbB-1 and ErbB-2 in meningioma.

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Expression of ErbB-1 and ErbB-2 in meningioma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wickremesekera, Agadha Hovens, Christopher M. Kaye, Andrew H.
Description	Country affiliation: New Zealand Author Affiliation: Wickremesekera A ( Department of Neurosurgery, Wellington Hospital, Riddiford Street, Newtown, Wellington 6021, New Zealand. Agadha.Wickremesekera@ccdhb.org.nz)
Abstract	Meningiomas are benign intracranial tumours treated by neurosurgical resection. Residual or recurrent tumour may be treated with radiotherapy. Effective molecular therapy for residual and recurrent meningiomas is currently unavailable. We tested meningiomas for In-ErbB-1 and ErbB-2, and the levels were compared to normal brain, peripheral nerve, glioblastoma multiforme and vestibular schwannoma. Our findings with immunohistochemistry and western blot analysis indicate a level of ErbB-1 similar to normal peripheral nerve, but a high expression of ErbB-2 similar to the vestibular schwannoma and glioblastoma multiforme. These preliminary results implicate a potential role for ErbB-2 in the benign tumourigenesis of meningioma consistent with the theoretical hierarchical interactions of homodimers of ErbB-2 that may be associated with low signal transduction.
File Format	HTM / HTML
ISSN	09675868
Issue Number	9
Volume Number	17
e-ISSN	15322653
Journal	Journal of Clinical Neuroscience
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Gene Expression Regulation, Neoplastic Meningeal Neoplasms Metabolism Meningioma Receptor, Epidermal Growth Factor Biosynthesis Receptor, Erbb-2 Humans Genetics Pathology Peripheral Nerves Protein Multimerization Signal Transduction Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology Physiology (medical) Neurology (clinical) Surgery

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