NDLI: Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

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Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Ji Seon Kim, Jong-Min Jeong-Ja, O. Jeon, Beom S.
Description	Country affiliation: South Korea Author Affiliation: Kim JS ( Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi-Dong, Seongnam, Seoul 463-707, South Korea.)
Abstract	The aim of this study was to investigate the involvement of inducible nitric oxide synthase (iNOS) in the action of (-)-epigallocatechin-3-gallate (EGCG), a potential neuroprotective agent against Parkinson's disease (PD), and to test for toxicity resulting from high doses of EGCG. EGCG was administered to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice at two different doses (10mg/kg and 50mg/kg). EGCG treatment reduced the neuronal death rate to less than 50%. The level of iNOS expression in the MPTP group was 20% higher than that seen in the control group, but in the EGCG groups, iNOS expression was reduced to the level observed in the negative control group. The two doses of EGCG were equally beneficial for cell rescue, and no toxicity was observed with the higher dose. Inhibition of iNOS may be an important mechanism underlying the prevention of MPTP toxicity, and EGCG may potentially be a neuroprotective agent against PD.
File Format	HTM / HTML
ISSN	09675868
Issue Number	9
Volume Number	17
e-ISSN	15322653
Journal	Journal of Clinical Neuroscience
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Catechin Analogs & Derivatives Disease Models, Animal Gene Expression Regulation, Enzymologic Drug Effects Mptp Poisoning Enzymology Nitric Oxide Synthase Type Ii Antagonists & Inhibitors Parkinsonian Disorders Drug Therapy Animals Pharmacology Therapeutic Use Cell Death Physiology Enzyme Inhibitors Male Mice Mice, Inbred C57bl Biosynthesis Tea Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology Physiology (medical) Neurology (clinical) Surgery

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Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

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Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

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