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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Arellano, Cécile Gandia, Peggy Bettuing, Laure Woodley, John Chatelut, Etienne |
| Description | Country affiliation: France Author Affiliation: Arellano C ( EA3035 Clinique et Expérimentale de Médicaments Anticancereux, Institut Claudius Regaud, 31052 Toulouse, France. arellano@cict.fr) |
| Abstract | Topetecan is an important anti-cancer drug that has recently become available as an oral formulation. In order to study its intestinal absorption in vitro and a potential drug-drug interaction with the anti-emetic ondansetron, a sensitive and accurate method for the analysis of topotecan in biological media was required. We developed a liquid-liquid extraction method at pH 7.0-7.5 with a recovery of 85% and which took into account the complex chemical behaviour of topotecan related to the lactone opening and the keto-enol tautomerism. This enabled us to validate a new specific and sensitive LC-MS method of analysis, with satisfactory inter- and intra-day repeatability and accuracy. The method was applied to a study of topotecan uptake in rat everted gut sacs that showed that, despite being a P-glycoprotein substrate like topotecan, ondansetron did not interfere with topotecan uptake. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Issue Number | 7-8 |
| Volume Number | 878 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Chromatography, Liquid Methods Duodenum Metabolism Mass Spectrometry Topotecan Analysis Pharmacokinetics Animals Antiemetics Pharmacology Antineoplastic Agents Drug Interactions Chemistry Drug Effects Hydrogen-ion Concentration Least-squares Analysis Male Models, Biological Ondansetron Rats Rats, Sprague-dawley Reproducibility Of Results Sensitivity And Specificity Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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