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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ptácek, Pavel Klíma, Josef Macek, Jan |
| Description | Country affiliation: Czech Republic Author Affiliation: Ptácek P ( Pharmakl s.r.o., Seydlerova 2451, CZ-15800 Prague 13, Czech Republic.) |
| Abstract | A liquid chromatography-electrospray tandem mass spectrometry method was developed and validated to quantitate celecoxib in human plasma. The assay was based on protein precipitation with methanol and liquid chromatography on a C18 column (55 mm × 2 mm, 3 µm), the mobile phase consisted of methanol-10 mM ammonium acetate (75:25, v/v). Quantification was performed by mass spectrometry in the multiple reaction monitoring mode with negative electrospray ionization at m/z 380â316 and 384â320 for celecoxib and the internal standard celecoxib-D4, respectively. The lower limit of quantitation was 7.0 ng/ml using 0.1 ml of plasma and linearity was demonstrated up to 1800 ng/ml. Intra-assay and inter-assay precision expressed by relative standard deviation was less than 4% and inaccuracy did not exceed 6% at all levels. The assay was applied to the analysis of samples from a pharmacokinetic study. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Volume Number | 899 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Chromatography, High Pressure Liquid Methods Cyclooxygenase 2 Inhibitors Blood Plasma Chemistry Pyrazoles Sulfonamides Tandem Mass Spectrometry Adolescent Adult Celecoxib Humans Male Middle Aged Spectrometry, Mass, Electrospray Ionization Young Adult Evaluation Studies Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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