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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Taneja, Isha Raju, Kanumuri Siva Rama Challagundla, Muralikrishna Raghuvanshi, Ashutosh Goel, Atul Wahajuddin, Muhammad |
| Description | Country affiliation: India Author Affiliation: Taneja I ( Academy of Scientific and Innovative Research, New Delhi, India); Raju KS ( Academy of Scientific and Innovative Research, New Delhi, India); Challagundla M ( National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, India.); Raghuvanshi A ( Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.); Goel A ( Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.); Wahajuddin M ( Academy of Scientific and Innovative Research, New Delhi, India) |
| Abstract | Medicarpin is the active phytoalexin found in the stem bark of Butea monosperma having potent osteogenic activity. An LC-ESI-MS/MS was developed and validated for quantification of medicarpin in rat plasma using liquid-liquid extraction technique and diethyl ether as the extraction solvent. Medicarpin was separated on RP18 column (4.6mm×50mm, 5.0µm) using methanol and 10mM ammonium acetate (pH 4.0) in the ratio of 80:20 (v/v) as mobile phase. The method was linear within the concentration range of 1-500ng/mL and its sensitivity was 1ng/mL. The precision value for intra- and inter-day assays and stability assays was within 0.88-14.22% while the accuracy ranged between 87.46-116.0% at all four QC levels. The validated method was successfully applied to study the preclinical pharmacokinetics of medicarpin in rats. Medicarpin showed multiple peak phenomenon upon oral administration. Its oral bioavailability was 17.43%. It was found to be a rapidly absorbed (Tmax=15min), 81.61% protein bound and pH stable compound. The present study provides important information regarding preliminary pharmacokinetics of medicarpin for its further exploration as a potential therapeutic agent. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Volume Number | 1001 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Chromatography, Liquid Methods Pterocarpans Analysis Sesquiterpenes Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Animals Limit Of Detection Protein Binding Pharmacokinetics Rats Reproducibility Of Results Journal Article Research Support, Non-u.s. Gov't Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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