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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cui, Xinge Huang, Jie Zheng, Xin Jiang, Ji Kuang, Yun Hu, Pei |
| Description | Country affiliation: China Author Affiliation: Cui X ( Clinical Pharmacology Research Center, Peking Union Medical College Hospital, China.); Huang J ( Center of Clinical Pharmacology, Third Xiangya Hospital, Central South University, China.); Zheng X ( Clinical Pharmacology Research Center, Peking Union Medical College Hospital, China.); Jiang J ( Clinical Pharmacology Research Center, Peking Union Medical College Hospital, China.); Kuang Y ( Center of Clinical Pharmacology, Third Xiangya Hospital, Central South University, China.); Hu P ( Clinical Pharmacology Research Center, Peking Union Medical College Hospital, China. Electronic address: pei.hu.pumch@gmail.com.) |
| Abstract | Roflumilast had shown good efficacy and safety in Caucasian COPD patients after oral administration of 0.5mg. The main active metabolite of it is roflumilast N-oxide. A reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantitation method was developed for the simultaneous determination of them in human plasma with rather low limits of quantitation for roflumilast (0.02ng/mL) and roflumilast N-oxide (0.04ng/mL). Human plasma samples were prepared by solid phase extraction (SPE), which ensured high recovery and slight matrix effect for the both analytes. This method showed good linearity, accuracy, precision and stability in the range of 0.02-10ng/mL and 0.04-50ng/mL for roflumilast and roflumilast N-oxide respectively. The developed method was successfully applied for the pharmacokinetic research in Chinese healthy volunteers after oral administration of 0.25mg, 0.375mg and 0.5mg of roflumilast tablet. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Journal | Journal of Chromatography B |
| Volume Number | 1029-1030 |
| e-ISSN | 1873376X |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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