NDLI: Bacterial translocation in HIV-infected patients with HCV cirrhosis: implication in hemodynamic alterations and mortality.

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Bacterial translocation in HIV-infected patients with HCV cirrhosis: implication in hemodynamic alterations and mortality.

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Bacterial translocation in HIV-infected patients with HCV cirrhosis: implication in hemodynamic alterations and mortality.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	de Oca Arjona, Montserrat Montes Marquez, Mercedes Soto, Maria Jose Rodriguez-Ramos, Claudio Terron, Alberto Vergara, Antonio Arizcorreta, Ana Fernandez-Gutierrez, Clotilde Giron-González, Jose Antonio
Description	Country affiliation: Spain Author Affiliation: de Oca Arjona MM ( Internal Medicine Department, Hospital Universitario Puerta del Mar, Cádiz, Spain. joseantonio.giron@uca.es)
Abstract	OBJECTIVE: Analysis of the influence of portal hypertension on intestinal permeability in HIV-infected patients with hepatitis C virus (HCV)-related cirrhosis and of the prognostic significance of consequent macrophage activation. METHODS: Twenty HIV-monoinfected patients, 70 patients with HIV-HCV coinfection, 20 of them with compensated and 50 with decompensated cirrhosis, and 20 healthy controls were evaluated for intestinal permeability [measured by lipopolysaccharide-binding protein (LBP) serum levels], macrophage activation [soluble CD14, soluble tumour necrosis factor receptor 55 Kd, and interleukin 6 (IL-6)], and activation of the rennin-angiotensin-aldosterone axis. Patients with decompensated cirrhosis were monitored for a median period of 429 days to analyze the prognostic factors implicated in survival. RESULTS: Patients with decompensated cirrhosis show increased LBP levels compared with HIV-monoinfected patients. Patients with increased LBP concentration showed elevated soluble CD14, soluble tumour necrosis factor receptor 55 Kd, and IL-6 levels. Twenty-two patients died, from liver-related causes, during the follow-up, and 2 more underwent liver transplantation. Child-Pugh index, CD4 T-cell count, plasma aldosterone and serum IL-6 concentrations independently predicted liver-related mortality. CONCLUSIONS: Increased intestinal permeability, as measured by serum LBP levels, observed in patients with HIV infection is significantly higher in patients with decompensated liver cirrhosis. Proinflammatory cytokines (IL-6) are prognostic markers of HIV-HCV-coinfected patients with decompensated cirrhosis.
File Format	HTM / HTML
ISSN	15254135
Issue Number	5
Volume Number	56
e-ISSN	10779450
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2011-04-15
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline AIDS Bacterial Translocation Physiology Hiv Infections Complications Hepatitis C Hypertension, Portal Intestines Microbiology Liver Cirrhosis Acute-phase Proteins Adult Carrier Proteins Blood Female Mortality Virology Hiv-1 Hepacivirus Humans Interleukin-6 Physiopathology Macrophage Activation Male Membrane Glycoproteins Middle Aged Permeability Prognosis Survival Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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Bacterial translocation in HIV-infected patients with HCV cirrhosis: implication in hemodynamic alterations and mortality.

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Bacterial translocation in HIV-infected patients with HCV cirrhosis: implication in hemodynamic alterations and mortality.