NDLI: Cancer in HIV-infected persons from the Caribbean, Central and South America.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fink, Valeria I. Shepherd, Bryan E. Cesar, Carina Krolewiecki, Alejandro Wehbe, Firas Cortés, Claudia P. Crabtree-Ramírez, Brenda Padgett, Denis Shafaee, Maryam Schechter, Mauro Gotuzzo, Eduardo Bacon, Melanie McGowan, Catherine Cahn, Pedro Masys, Daniel
Spatial Coverage	South America Central America Caribbean Region
Description	Country affiliation: Argentina Author Affiliation: Fink VI ( Huésped, Investigaciones Clínicas, Buenos Aires, Argentina. valeria.fink@huesped.org.ar)
Abstract	BACKGROUND: HIV-infected individuals have heightened cancer risk. With the advent of highly active antiretroviral therapy (HAART), the frequency of some AIDS-defining cancers (ADC) has decreased although certain non-AIDS-defining cancers (NADC) are becoming more frequent. Cancers among HIV-infected individuals in Latin American and the Caribbean have not yet been carefully studied. METHODS: Cancer cases among the Caribbean, Central and South American network for HIV Research (CCASAnet) cohort were identified reviewing clinical records and pre-existing databases. RESULTS: There were 406 cancers reported: 331 ADC (224 Kaposi sarcomas and 98 non Hodgkin lymphomas). Most frequent NADC (n = 75) were Hodgkin lymphoma and skin cancers. Seventy-three percent of NADC and 45% of ADC were diagnosed >1 year after HIV diagnosis. Fifty-six percent of ADC occurred before HAART start. Median time from HAART start until cancer diagnosis was 2.5 years for NADC and 0.5 years for ADC (P = <0.001). Within 3372 HAART starters, 158 were diagnosed with 165 cancers (82.4% ADC); 85 cases were previous to or concomitant with HAART initiation. Incidence of cancer after HAART initiation in 8080 person-years of follow-up was 7.2 per 1000 person-years (95% confidence interval = 5.5 to 9.3) for ADC and 2.7 (95% confidence interval = 1.8 to 4.1) for NADC; incidence was higher in the first 2 months, particularly for ADC (47.6). A pre-HAART ADC was a predictor of mortality after adjusting for age, sex, and CD4 at HAART initiation. CONCLUSIONS: ADC were the most frequent cancers in this region and were often diagnosed close to HIV diagnosis and HAART start. Incidence of cancer was highest around HAART initiation.
File Format	HTM / HTML
ISSN	15254135
e-ISSN	10779450
DOI	10.1097/QAI.0b013e31820bb1c3
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Issue Number	5
Volume Number	56
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2011-04-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline AIDS Hiv Infections Epidemiology Lymphoma, Aids-related Neoplasms Complications Sarcoma, Kaposi Antiretroviral Therapy, Highly Active Caribbean Region Central America Cohort Studies Diagnosis Drug Therapy Hodgkin Disease Classification South America Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Human immunodeficiency virus-associated lung malignancies.

Effect of HAART on incident cancer and noncancer AIDS events among male HIV seroconverters.

Continuing declines in some but not all HIV-associated cancers in Australia after widespread use of antiretroviral therapy.

Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretroviral therapy: prospective cohort study. Swiss HIV Cohort Study.

Mortality during the first year of potent antiretroviral therapy in HIV-1-infected patients in 7 sites throughout Latin America and the Caribbean.

Immunologic and virologic predictors of AIDS-related non-hodgkin lymphoma in the highly active antiretroviral therapy era.

The effect of HAART and calendar period on Kaposi's sarcoma and non-Hodgkin lymphoma: results of a match between an AIDS and cancer registry.

Factors associated with mortality among HIV-infected patients in the era of highly active antiretroviral therapy in southern India.

Mortality after cancer diagnosis in HIV-infected individuals treated with antiretroviral therapy.

Cancer in HIV-infected persons from the Caribbean, Central and South America.

Similar Documents

Human immunodeficiency virus-associated lung malignancies.

Effect of HAART on incident cancer and noncancer AIDS events among male HIV seroconverters.

Continuing declines in some but not all HIV-associated cancers in Australia after widespread use of antiretroviral therapy.

Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretroviral therapy: prospective cohort study. Swiss HIV Cohort Study.

Mortality during the first year of potent antiretroviral therapy in HIV-1-infected patients in 7 sites throughout Latin America and the Caribbean.

Immunologic and virologic predictors of AIDS-related non-hodgkin lymphoma in the highly active antiretroviral therapy era.

The effect of HAART and calendar period on Kaposi's sarcoma and non-Hodgkin lymphoma: results of a match between an AIDS and cancer registry.

Factors associated with mortality among HIV-infected patients in the era of highly active antiretroviral therapy in southern India.

Mortality after cancer diagnosis in HIV-infected individuals treated with antiretroviral therapy.

Cancer in HIV-infected persons from the Caribbean, Central and South America.