NDLI: Low prevalence of transmitted drug resistance of HIV-1 during 2008-2012 antiretroviral therapy scaling up in Southern Vietnam.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tanuma, Junko Quang, Vo Minh Hachiya, Atsuko Joya, Akane Watanabe, Koji Gatanaga, Hiroyuki Van Vinh Chau, Nguyen Chinh, Nguyen Tran Oka, Shinichi
Spatial Coverage	Vietnam
Description	Country affiliation: Japan Author Affiliation: Tanuma J ( *AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan)
Abstract	BACKGROUND: The recent expansion of antiretroviral therapy (ART) program in resource-limited setting has raised concern about possible transmission of drug resistance (TDR). We assessed the prevalence of TDR over a 5-year period among treatment-naive individuals in Southern Vietnam during rapid ART scale-up. METHODS: Drug resistance mutations among antiretroviral-naive HIV-1-infected patients in Ho Chi Minh City were evaluated prospectively from 2008 to 2012 by HIV-1 pol gene sequencing. TDR was defined according to the World Health Organization list for surveillance of transmitted HIV-1 drug resistance in 2009. RESULTS: Pol sequence was obtained in 1389 individuals (median age: 30 years, males: 52.3%). Risks of HIV-1 infection included heterosexual contact in 60.7%, injection drug use in 22.4% and both 5.2%. The majority was infected with CRF01_AE (97%), whereas 19 were infected with subtype B. Over the 5-year study period, TDR was detected in 58 individuals (4.18%): 28 (2.02%) against nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), 19 (1.37%) against nonnucleoside reverse transcriptase inhibitors (NNRTIs), and 15 (1.08%) against protease inhibitors (PIs), including 4 (0.29%) against both NRTIs and NNRTIs. The most common TDR was K103N (0.5%) for NNRTI. The annual prevalence of TDR remained low to moderate (2008: 2.4%; 2009: 5.2%; 2010: 5.48%; 2011: 2.72%; 2012: 5.36%), and there was no clear trend over time. CONCLUSIONS: There was no increase in TDR prevalence in Southern Vietnam during and after the 2008-2012 rapid scale up of ART.
File Format	HTM / HTML
ISSN	15254135
Issue Number	4
Volume Number	66
e-ISSN	10779450
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2014-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline AIDS Anti-hiv Agents Pharmacology Therapeutic Use Hiv Infections Drug Therapy Virology Hiv-1 Drug Effects Adult Drug Resistance, Viral Female Genotype Epidemiology Humans Male Mutation Prevalence Vietnam Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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