NDLI: A prospective cohort study of the effect of depot medroxyprogesterone acetate on detection of plasma and cervical HIV-1 in women initiating and continuing antiretroviral therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Day, Summer Graham, Susan M. Masese, Linnet N. Richardson, Barbra A. Kiarie, James N. Jaoko, Walter Mandaliya, Kishorchandra Chohan, Vrasha Overbaugh, Julie McClelland, R. Scott
Spatial Coverage	Kenya
Description	Country affiliation: Kenya Author Affiliation: Day S ( *Department of Medicine, University of Washington, Seattle, WA)
Abstract	Depot medroxyprogesterone acetate (DMPA) use among HIV-1-infected women may increase transmission by increasing plasma and genital HIV-1 RNA shedding. We investigated associations between DMPA use and HIV-1 RNA in plasma and cervical secretions. One hundred two women initiated antiretroviral therapy, contributing 925 follow-up visits over a median of 34 months. Compared with visits with no hormonal contraception exposure, DMPA exposure did not increase detection of plasma (adjusted odds ratio: 0.81, 95% confidence interval: 0.47 to 1.39) or cervical HIV-1 RNA (adjusted odds ratio: 1.41, 95% confidence interval: 0.54 to 3.67). Our results suggest that DMPA is unlikely to increase infectivity in HIV-positive women who are adherent to effective antiretroviral therapy.
File Format	HTM / HTML
ISSN	15254135
e-ISSN	10779450
DOI	10.1097/QAI.0000000000000187
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Issue Number	4
Volume Number	66
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2014-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline AIDS Anti-hiv Agents Therapeutic Use Cervix Mucus Virology Hiv Infections Blood Diagnosis Hiv-1 Isolation & Purification Medroxyprogesterone Acetate Pharmacology Administration & Dosage Cohort Studies Cross-sectional Studies Delayed-action Preparations Epidemiology Kenya Rna, Viral Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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Changes in Vaginal Microbiota and Immune Mediators in HIV-1-Seronegative Kenyan Women Initiating Depot Medroxyprogesterone Acetate.

A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy

Depot Medroxyprogesterone Acetate Use Is Associated With Elevated Innate Immune Effector Molecules in Cervicovaginal Secretions of HIV-1-Uninfected Women.

Tenofovir disoproxil fumarate intravaginal ring protects high-dose depot medroxyprogesterone acetate-treated macaques from multiple SHIV exposures.

Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women.

Preexposure prophylaxis is efficacious for HIV-1 prevention among women using depot medroxyprogesterone acetate for contraception.

Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding.

Prevalence and persistence of cervical human papillomavirus infection in HIV-positive women initiating highly active antiretroviral therapy.

Hormonal contraceptive use and HIV disease progression among women in Uganda and Zimbabwe.

A prospective cohort study of the effect of depot medroxyprogesterone acetate on detection of plasma and cervical HIV-1 in women initiating and continuing antiretroviral therapy.

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Changes in Vaginal Microbiota and Immune Mediators in HIV-1-Seronegative Kenyan Women Initiating Depot Medroxyprogesterone Acetate.

A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy

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