NDLI: Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.

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Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Helmrich, Anne Stout-Weider, Karen Hermann, Klaus Schrock, Evelin Heiden, Thomas
Description	Country affiliation: Germany Author Affiliation: Helmrich A ( Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, University of Technology, 01307 Dresden, Germany. anneh@titus.u-strasburg.fr)
Abstract	Common fragile sites (CFSs) are seen as chromosomal gaps and breaks brought about by inhibition of replication, and it is thought that they cluster with tumor breakpoints. This study presents a comprehensive analysis using conventional and molecular cytogenetic mapping of CFSs and their expression frequencies in two mouse strains, BALB/c and C57BL/6, and in human probands. Here we show that induced mouse CFSs relate to sites of spontaneous gaps and breaks and that CFS expression levels in chromosome bands are conserved between the two mouse strains and between syntenic mouse and human DNA segments. Furthermore, four additional mouse CFSs were found to be homologous to human CFSs on the molecular cytogenetic level (Fra2D-FRA2G, Fra4C2-FRA9E, Fra6A3.1-FRA7G, and Fra6B1-FRA7H), increasing the number of such CFSs already described in the literature to eight. Contrary to previous reports, DNA helix flexibility is not increased in the 15 human and eight mouse CFSs molecularly defined so far, compared to large nonfragile control regions. Our findings suggest that the mechanisms that provoke instability at CFSs are evolutionarily conserved. The role that large transcriptionally active genes may play in CFS expression is discussed.
File Format	HTM / HTML
ISSN	10889051
e-ISSN	15495469
Journal	Genome Research
Issue Number	10
Volume Number	16
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2006-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Genetics Discipline Genomics Chromosome Fragile Sites Genetics Chromosome Mapping Conserved Sequence Chemistry Gene Expression Profiling Mice Animals Chromosomes, Artificial, Bacterial Computational Biology In Situ Hybridization, Fluorescence Mice, Inbred Balb C Mice, Inbred C57bl Species Specificity Comparative Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes

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Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.

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Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes

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Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.