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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huson, Daniel H. Mitra, Suparna Ruscheweyh, Hans-Joachim Weber, Nico Schuster, Stephan C. |
| Description | Country affiliation: Germany Author Affiliation: Huson DH ( Center for Bioinformatics, Tübingen University, Tübingen, Germany. huson@informatik.uni-tuebingen.de) |
| Abstract | A major challenge in the analysis of environmental sequences is data integration. The question is how to analyze different types of data in a unified approach, addressing both the taxonomic and functional aspects. To facilitate such analyses, we have substantially extended MEGAN, a widely used taxonomic analysis program. The new program, MEGAN4, provides an integrated approach to the taxonomic and functional analysis of metagenomic, metatranscriptomic, metaproteomic, and rRNA data. While taxonomic analysis is performed based on the NCBI taxonomy, functional analysis is performed using the SEED classification of subsystems and functional roles or the KEGG classification of pathways and enzymes. A number of examples illustrate how such analyses can be performed, and show that one can also import and compare classification results obtained using others' tools. MEGAN4 is freely available for academic purposes, and installers for all three major operating systems can be downloaded from www-ab.informatik.uni-tuebingen.de/software/megan. |
| File Format | HTM / HTML |
| ISSN | 10889051 |
| e-ISSN | 15495469 |
| DOI | 10.1101/gr.120618.111 |
| Journal | Genome Research |
| Issue Number | 9 |
| Volume Number | 21 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2011-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Genetics Discipline Genomics Metagenomics Classification Metagenome Genetics Proteomics Rna, Ribosomal, 16s Transcriptome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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