NDLI: Complex elaboration: making sense of meiotic cohesin dynamics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rankin, Susannah
Description	Country affiliation: United States Author Affiliation: Rankin S ( Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, OK, USA.)
Abstract	In mitotically dividing cells, the cohesin complex tethers sister chromatids, the products of DNA replication, together from the time they are generated during S phase until anaphase. Cohesion between sister chromatids ensures accurate chromosome segregation, and promotes normal gene regulation and certain kinds of DNA repair. In somatic cells, the core cohesin complex is composed of four subunits: Smc1, Smc3, Rad21 and an SA subunit. During meiotic cell divisions meiosis-specific isoforms of several of the cohesin subunits are also expressed and incorporated into distinct meiotic cohesin complexes. The relative contributions of these meiosis-specific forms of cohesin to chromosome dynamics during meiotic progression have not been fully worked out. However, the localization of these proteins during chromosome pairing and synapsis, and their unique loss-of-function phenotypes, suggest non-overlapping roles in controlling meiotic chromosome behavior. Many of the proteins that regulate cohesin function during mitosis also appear to regulate cohesin during meiosis. Here we review how cohesin contributes to meiotic chromosome dynamics, and explore similarities and differences between cohesin regulation during the mitotic cell cycle and meiotic progression. A deeper understanding of the regulation and function of cohesin in meiosis will provide important new insights into how the cohesin complex is able to promote distinct kinds of chromosome interactions under diverse conditions.
File Format	HTM / HTML
ISSN	1742464X
e-ISSN	17424658
DOI	10.1111/febs.13301
Journal	FEBS Journal
Issue Number	13
Volume Number	282
Language	English
Publisher	Wiley (on behalf of the Federation of European Biochemical Societies)
Publisher Date	2015-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Cell Cycle Proteins Physiology Chromosomal Proteins, Non-histone Meiosis Carrier Proteins Dna Damage Nuclear Proteins Phosphoproteins Phosphorylation Proto-oncogene Proteins Sex Characteristics Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Structure of the human cohesin inhibitor Wapl.

Meiotic cohesin complexes are essential for the formation of the axial element in mice

Recombination protein Tid1p controls resolution of cohesin-dependent linkages in meiosis in Saccharomyces cerevisiae

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Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.

Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity.

Spo13 protects meiotic cohesin at centromeres in meiosis I.

A handcuff model for the cohesin complex

Polo kinase Cdc5 is a central regulator of meiosis I.

Complex elaboration: making sense of meiotic cohesin dynamics.

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