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Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wilson, David I. G. MacLaren, Duncan A. A. Winn, Philip
Description	Country affiliation: United kingdom Author Affiliation: Wilson DI ( School of Psychology, University of St Andrews, St Mary's Quad, St Andrews, Fife, UK. digw@st-and.ac.uk)
Abstract	The pedunculopontine tegmental nucleus (PPTg) is in a key position to participate in operant reinforcement via its connections with the corticostriatal architecture and the medial reticular formation. Indeed, previous work has demonstrated that rats bearing lesions of the whole PPTg are impaired when learning to make two bar presses for amphetamine reinforcement. Anterior and posterior portions of the PPTg make different anatomical connections, including preferential projections by the anterior PPTg to substantia nigra pars compacta dopamine neurons and by the posterior PPTg to ventral tegmental area dopamine neurons. We wanted to assess the effects of anterior and posterior PPTg ibotenate lesions on rats learning simple and more complex schedules of natural reinforcement. We trained rats with lesions to the anterior PPTg (n = 11) and the posterior PPTg (n = 5) [and appropriate controls (n = 15)] to bar press for food on a variety of fixed-ratio and variable-ratio reinforcement schedules and then during extinction. We found that posterior PPTg-lesioned rats bar pressed at lower rates, were slower to learn to bar press, and often had deficits characteristic of impaired learning and/or motivation. In contrast, anterior PPTg-lesioned rats learned to bar press for reinforcement at normal rates. However, they made errors of perseveration and anticipation throughout many schedules, and pressed at a higher rate than controls during extinction, deficits best characterized as reflecting disorganized response control. Together, these data suggest that the anterior PPTg and posterior PPTg (and their related circuits) contribute differently to reinforcement learning, incentive motivation, and response control, processes that are considered to malfunction in drug addiction.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	3
Volume Number	30
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-08-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Behavior, Animal Physiology Learning Pedunculopontine Tegmental Nucleus Animals Conditioning, Operant Drug Effects Excitatory Amino Acid Agonists Toxicity Food Ibotenic Acid Male Injuries Rats Reinforcement (psychology) Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine.

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Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine.