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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | MacLaren, Duncan A. A. Santini, Joseph A. Russell, Ashley L. Markovic, Tamara Clark, Stewart D. |
| Description | Country affiliation: United States Author Affiliation: MacLaren DA ( Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, NY, 14214, USA.) |
| Abstract | Anatomically and functionally located between basal ganglia and brainstem circuitry, the pedunculopontine tegmental nucleus (PPTg) is in a pivotal position to contribute to motor behavior. Studies in primates have reported akinesia and postural instability following destruction of the PPTg. In humans, the PPTg partially degenerates in Parkinson's disease and stimulation of this region is under investigation as a possible therapeutic. Studies in rats report no crude motor impairment following PPTg lesion, although a detailed assessment of the role of the PPTg in rat motor function has not been reported. Our studies applied motor tests generally used in rodent models of Parkinson's disease to rats bearing either excitotoxic damage to all neuronal populations within PPTg, or selective destruction of the cholinergic subpopulation created with the toxin Dtx-UII. Neither lesion type altered baseline locomotion. On the rotarod, excitotoxic lesions produced a persistent impairment on the accelerating, but not fixed speed, conditions. In the vermicelli handling task (a quantitative measure of fine motor control and effective behavioral sequencing) excitotoxic lesions produced no single impairment, but globally increased the number of normal and abnormal behaviors. In contrast, depletion of cholinergic PPTg neurons produced impairment on the accelerating rotarod but no changes in vermicelli handling. Together, these results show that while PPTg lesions produce no impairment in the execution of individual motor actions, impairments emerge when the demands of the task increase. Results are discussed in terms of PPTg acting as part of a rapid action selection system, which integrates sensory information into motor output. |
| File Format | HTM / HTML |
| ISSN | 0953816X |
| Issue Number | 8 |
| Volume Number | 40 |
| e-ISSN | 14609568 |
| Journal | European Journal of Neuroscience |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-10-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neuroscience Cholinergic Neurons Physiology Motor Activity Neurons Pedunculopontine Tegmental Nucleus Animals Ibotenic Acid Toxicity Male Pathology Rats Rats, Sprague-dawley Rotarod Performance Test Journal Article Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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