NDLI: Climbing fiber synapse elimination in cerebellar Purkinje cells

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Climbing fiber synapse elimination in cerebellar Purkinje cells

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Climbing fiber synapse elimination in cerebellar Purkinje cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Watanabe, Masahiko Kano, Masanobu
Description	Country affiliation: Japan Author Affiliation: Watanabe M ( Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan. watamasa@med.hokudai.ac.jp)
Abstract	Innervation of Purkinje cells (PCs) by multiple climbing fibers (CFs) is refined into mono-innervation during the first three postnatal weeks of rodents’ lives. In this review article, we will integrate the current knowledge on developmental process and mechanisms of CF synapse elimination. In the ‘creeper’ stage of CF innervation (postnatal day 0 (P0)∼), CFs creep among PC somata to form transient synapses on immature dendrites. In the ‘pericellular nest’ stage (P5∼), CFs densely surround and innervate PC somata. CF innervation is then displaced to the apical portion of PC somata in the ‘capuchon’ stage (P9∼), and translocate to dendrites in the ‘dendritic’ (P12∼) stage. Along with the developmental changes in CF wiring, functional and morphological distinctions become larger among CF inputs. PCs are initially innervated by more than five CFs with similar strengths (∼P3). During P3–7 only a single CF is selectively strengthened (functional differentiation), and it undergoes dendritic translocation from P9 on (dendritic translocation). Following the functional differentiation, perisomatic CF synapses are eliminated nonselectively; this proceeds in two distinct phases. The early phase (P7–11) is conducted independently of parallel fiber (PF)–PC synapse formation, while the late phase (P12–17) critically depends on it. The P/Q-type voltage-dependent $Ca^{2+}$ channel in PCs triggers selective strengthening of single CF inputs, promotes dendritic translocation of the strengthened CFs, and drives the early phase of CF synapse elimination. In contrast, the late phase is mediated by the mGluR1–Gαq–PLCβ4–PKCγ signaling cascade in PCs driven at PF–PC synapses, whose structural connectivity is stabilized and maintained by the GluRδ2–Cbln1–neurexin system.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	10
Volume Number	34
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-11-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Cerebellum Cytology Nerve Fibers Ultrastructure Purkinje Cells Synapses Physiology Animals Receptor, Trkb Metabolism Rodentia Somatomedins Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses.

Type 2 K+ -Cl- cotransporter is preferentially recruited to climbing fiber synapses during development and the stellate cell-targeting dendritic zone at adulthood in cerebellar Purkinje cells.

PTPδ is a presynaptic organizer for formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum

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Climbing fiber synapse elimination in cerebellar Purkinje cells

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