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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abdo, Hind Li, Lili Lallemend, Francois Bachy, Isabelle Xu, Xiao-Jun Rice, Frank L. Ernfors, Patrik |
| Description | Country affiliation: Sweden Author Affiliation: Abdo H ( Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.) |
| Abstract | Touch sensation is mediated by specific subtypes of sensory neurons which develop in a hierarchical process from common early progenitor neurons, but the molecular mechanism that underlies diversification of touch-sensitive mechanoreceptive neurons is not fully known. Here, we use genetically manipulated mice to examine whether the transcription factor short stature homeobox 2 (Shox2) participates in the acquisition of neuronal subtypes conveying touch sensation. We show that Shox2 encodes the development of category I low-threshold mechanoreceptive neurons in glabrous skin, i.e. discriminative touch-sensitive neurons which form innervations of epidermal Merkel cell and Meissner corpuscles. In contrast, other sensory fiber endings, including those innervating Pacinian corpuscles, are not dependent on Shox2. Shox2 is expressed in neurons of most or all classes of sensory neurons at early embryonic stages and is later confined to touch-sensitive neurons expressing Ret and/or TrkB. Conditional deletion of Shox2 and analysis of Runx3(-/-);Bax(-/-) mutant mice reveals that Runx3 is suppressing Shox2 while Shox2 is necessary for TrkB expression, and that these interactions are necessary for diversification of TrkB(+) and TrkC(+) mechanoreceptive neurons. In particular, development of TrkB(+)/Ret(+) and TrkB(+)/Ret(-) touch-sensitive neurons is critically dependent on Shox2. Consistently, Shox2 conditional mutant mice demonstrate a dramatic impairment of light touch responses. These results show that Shox2 is required for specification of a subclass of TrkB(+) sensory neurons which convey the sensation of discriminative touch arising from stimuli of the skin. |
| File Format | HTM / HTML |
| ISSN | 0953816X |
| Issue Number | 10 |
| Volume Number | 34 |
| e-ISSN | 14609568 |
| Journal | European Journal of Neuroscience |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2011-11-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neuroscience Homeodomain Proteins Metabolism Sensory Receptor Cells Physiology Touch Animals Behavior, Animal Core Binding Factor Alpha 3 Subunit Genetics Female Ganglia, Spinal Cytology Humans Male Mechanoreceptors Mechanotransduction, Cellular Merkel Cells Mice Mice, Inbred C57bl Nociceptors Pacinian Corpuscles Proto-oncogene Proteins C-ret Receptor, Trkb Receptor, Trkc Touch Perception Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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