NDLI: Sediment genotoxicity in the Tietê River (São Paulo, Brazil): in vitro comet assay versus in situ micronucleus assay studies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rocha, Paula Suares Luvizotto, George Luiz Kosmehl, Thomas Böttcher, Melanie Storch, Volker Braunbeck, Thomas Hollert, Henner
Spatial Coverage	Brazil
Description	Country affiliation: Germany Author Affiliation: Rocha PS ( Aquatic Ecology and Toxicology Section, Heidelberg Institute of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany. rocha@zoo.uni-heidelberg.de)
Abstract	The in vitro comet assay with the permanent fish cell line RTL-W1 and the in situ micronucleus assay using erythrocytes from indigenous tilapia (Oreochromis niloticus) were used to detect genotoxicity in Tietê River sediments (São Paulo, Brazil). Either test was successful in identifying site-specific differences in genotoxicity, with a high correlation between in situ and in vitro results indicating the relevance of the latter even for environmental studies. Discharges from São Paulo city have major impact on genotoxic effects by sediment-bound contaminants; however, overall genotoxicity decreases downstream. The high genotoxic burden of the Tietê River warrants measures to reduce the input of toxic effluents.
File Format	HTM / HTML
ISSN	01476513
Issue Number	7
Volume Number	72
e-ISSN	10902414
Journal	Ecotoxicology and Environmental Safety
Language	English
Publisher	Elsevier
Publisher Date	2009-10-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Sciences Dna Damage Environmental Monitoring Methods Geologic Sediments Chemistry Micronuclei, Chromosome-defective Chemically Induced Rivers Water Pollutants, Chemical Toxicity Animals Brazil Cell Line Comet Assay Erythrocytes Drug Effects Fibroblasts Liver Cytology Micronucleus Tests Oncorhynchus Mykiss Tilapia Blood Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health

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