NDLI: Modulation of DNA damage and alteration of gene expression during aflatoxicosis via dietary supplementation of Spirulina (Arthrospira) and Whey protein concentrate.

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Modulation of DNA damage and alteration of gene expression during aflatoxicosis via dietary supplementation of Spirulina (Arthrospira) and Whey protein concentrate.

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Modulation of DNA damage and alteration of gene expression during aflatoxicosis via dietary supplementation of Spirulina (Arthrospira) and Whey protein concentrate.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hassan, Aziza M. Abdel-Aziem, Sekena H. Abdel-Wahhab, Mosaad A.
Description	Country affiliation: Egypt Author Affiliation: Hassan AM ( Cell Biology Department, National Research Center, Dokki, Cairo, Egypt.)
Abstract	Spirulina (SPN) and Whey protein (WPC) are being touted as functional foods with a number of health benefits. SPN is blue green algae while WPC is a protein complex derived from milk and both have strong antioxidant activity and provoke a free radical scavenging enzyme system. The aim of the present study was to evaluate the antioxidant potentials of SPN and WPC to regulate the alteration of genes' expression and counteract oxidative stress in rats during aflatoxecosis. Eighty male Sprague-Dawley rats were divided into eight groups, which included the control group, the group fed with aflatoxins (AFs)-contaminated diet (2.5 mg/kg diet) for 30 day, the group treated orally with WPC (300 mg/kg b.w.), the group treated orally with SPN (50 mg/kg b.w), the group treated orally with WPC plus SPN and the groups fed with AFs-contaminated diet and treated orally with WPC, SPN and/or WPC. Oxidative stress markers and gene expression were assayed in liver and testis and the damage of DNA was evaluated by DNA fragmentation and micronucleus tests. The results demonstrated that supplementation of SPN and/or WPC reduced the oxidative stress induced by AFs as indicated by decreased lipid peroxidation level, increased glutathione content and up-regulated PHGPx gene expression. Both agents succeed to inhibit DNA damage as indicated by the down-regulation of Fas gene expression, and decreased the percentage of DNA fragmentation and micronucleated erythrocytes. Moreover, WPC was found to be effective than SPN and the combined treatment was more effective than the single treatment. It could be concluded that both SPN and WPC induced a protective action and regulated the alteration of genes expression induced by AFs; however, the combined treatment may be useful than the single treatment.
File Format	HTM / HTML
ISSN	01476513
Volume Number	79
e-ISSN	10902414
Journal	Ecotoxicology and Environmental Safety
Language	English
Publisher	Elsevier
Publisher Date	2012-05-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Sciences Antioxidants Pharmacology Dietary Supplements Gene Expression Regulation Milk Proteins Spirulina Aflatoxins Toxicity Animals Dna Damage Down-regulation Drug Effects Erythrocytes Metabolism Gene Expression Glutathione Glutathione Peroxidase Lipid Peroxidation Liver Male Oxidative Stress Poisons Rats Rats, Sprague-dawley Testis Whey Proteins Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health

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