| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Silva, Francisca A. E. Siopa, Filipa Figueiredo, Bruna F. H. T. Gonçalves, Ana M. M. Pereira, Joana L. Gonçalves, Fernando Coutinho, João A. P. Afonso, Carlos A. M. Ventura, Sónia P. M. |
| Description |
Country affiliation: Portugal Author Affiliation: E Silva FA ( CICECO, Departamento de Química, Universidade de Aveiro, 3810-193 Aveiro, Portugal.); Siopa F ( Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.); Figueiredo BF ( CICECO, Departamento de Química, Universidade de Aveiro, 3810-193 Aveiro, Portugal.); Gonçalves AM ( Departamento de Biologia, CESAM (Centro de Estudos do Ambiente e do Mar), Universidade de Aveiro, 3810-193 Aveiro, Portugal); Pereira JL ( Departamento de Biologia, CESAM (Centro de Estudos do Ambiente e do Mar), Universidade de Aveiro, 3810-193 Aveiro, Portugal.); Gonçalves F ( Departamento de Biologia, CESAM (Centro de Estudos do Ambiente e do Mar), Universidade de Aveiro, 3810-193 Aveiro, Portugal.); Coutinho JA ( CICECO, Departamento de Química, Universidade de Aveiro, 3810-193 Aveiro, Portugal.); Afonso CA ( Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.); Ventura SP ( CICECO, Departamento de Química, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address: spventura@ua.pt.) |
| Abstract |
Cholinium-based ionic liquids are receiving crescent interest in diverse areas of application given their biological compatibility and potential for industrial application. In this work, mono and dicationic cholinium ionic liquids as well as cholinium derivatives were synthesized and their toxicity assessed using the luminescent bacteria Vibrio fischeri. A range of cholinium derivatives was synthesized, using different amines and the correspondent brominated derivatives, through the alkylation of the amine with the halide in MeCN. The results indicate that their toxicity is highly dependent on the structural modifications of the cholinium cation, mainly related to the alkyl side or linkage chain length, number of hydroxyethyl groups and insertion of carbon-carbon multiple bonds. The data indicated that it is possible to perform environmentally advantageous structural alterations, namely the addition of double bonds, which would not negatively affect V. fischeri. Moreover, the dicationic compounds revealed a significantly lower toxicity than the monocationic counterparts. The picture emerging from the results supports the idea that cholinium derivatives are promising ionic liquids with a low environmental impact, emphasizing the importance of a careful and directed design of ionic liquid structures. |
| File Format |
HTM / HTML |
| ISSN |
01476513 |
| Journal |
Ecotoxicology and Environmental Safety |
| Volume Number |
108 |
| e-ISSN |
10902414 |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-10-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Environmental Sciences Ionic Liquids Toxicity Aliivibrio Fischeri Cations Green Chemistry Technology Chemistry Toxicity Tests Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
