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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Fuhai Lu, Guanghua Liu, Jianchao Yan, Zhenhua Zhang, Zhenghua |
| Description | Author Affiliation: Zhang F ( Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, PR China); Lu G ( Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, PR China. Electronic address: ghlu@hhu.edu.cn.); Liu J ( Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, PR China.); Yan Z ( Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, PR China.); Zhang Z ( Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, PR China.) |
| Abstract | Polybrominated diphenyl ethers (PBDEs) are of great environmental concern due to bioaccumulation and biomagnification in different food chains. However, significant biotransformation of some congeners via reductive debromination has been observed during in vivo and in vitro laboratory exposures. Little is known about the fate of 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153) in fish. In the present study, crucian carp (Carassius auratus) were exposed to BDE-153 at a concentration of 10µg/g in food for 28 days. BDE-153 and its metabolites in different tissues were identified and quantified using gas chromatography coupled with tandem mass spectrometry and ultra-high performance liquid chromatography coupled with tandem mass spectrometry. In addition to eight debrominated metabolites, four oxidative metabolites were detected 4'-hydroxy-2,2',4,5'-tetra-BDE, 6-hydroxy-2,2',4,4'-tetra-BDE, 2,4-dibromophenol and 2,4,6-tribromophenol. With regard to the concentrations of BDE-153 and the major metabolites, the contribution order of different tissues was bile>brain>liver>gill>muscle. The highest concentrations of BDE-153 and metabolite 2,2',4,4'-tetrabromodiphenyl ether were detected in bile at 808ng/g and 157ng/g, respectively. Our results suggested that three possible metabolic pathways of BDE-153 occurred in crucian carp via dietary exposure: debromination, hydroxylation and cleavage of the diphenyl ether bond. These findings indicated evidence of the bioavailability of BDE-153 from food in the form of debrominated metabolites and oxidative metabolites in freshwater fish, which is critical to understanding the complete risks associated with PBDE bioaccumulation and metabolism in humans and wildlife. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Volume Number | 108 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Goldfish Metabolism Halogenated Diphenyl Ethers Polybrominated Biphenyls Animals Biotransformation Diet Fresh Water Pharmacokinetics Hydroxylation Liver Tandem Mass Spectrometry Tissue Distribution Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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