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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nanno, Katsuhiko Sugiyasu, Kenjiro Daimon, Takashi Yoshikawa, Hideki Myoui, Akira |
| Description | Country affiliation: Japan Author Affiliation: Nanno K ( Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.) |
| Abstract | Bone morphogenetic proteins (BMPs) can induce bone formation in vivo when combined with appropriate carriers. Several materials, including animal collagens and synthetic polymers, have been evaluated as carriers for BMPs. We examined alginate, an approved biomaterial for human use, as a carrier for BMP-7. In a mouse model of ectopic bone formation, the following four carriers for recombinant human OP-1 (BMP-7) were tested: alginate crosslinked by divalent cations (DC alginate), alginate crosslinked by covalent bonds (CB alginate), Type I atelocollagen, and poly-D,L-lactic acid-polyethyleneglycol block copolymer (PLA-PEG). Discs of carrier materials (5-mm diameter) containing OP-1 (3-30 microg) were implanted beneath the fascia of the back muscles in six mice per group. These discs were recovered 3 weeks after implantation and subjected to radiographic and histologic studies. Ectopic bone formation occurred in a dose-dependent manner after the implantation of DC alginate, atelocollagen, and PLA-PEG, but occurred only at the highest dose implanted with CB alginate. Bone formation with DC alginate/OP-1 composites was equivalent to that with atelocollagen/OP-1 composites. Our data suggest DC alginate, a material free of animal products that is already approved by the FDA and other authorities, is a safe and potent carrier for OP-1. This carrier may also be applicable to various other situations in the orthopaedic field. |
| File Format | HTM / HTML |
| ISSN | 0009921X |
| e-ISSN | 15281132 |
| DOI | 10.1007/s11999-009-0899-2 |
| Journal | Clinical Orthopaedics and Related Researchtextregistered |
| Issue Number | 12 |
| Volume Number | 467 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2009-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Orthopaedics Alginates Chemistry Bone Morphogenetic Protein 7 Pharmacology Drug Carriers Ossification, Heterotopic Chemically Induced Osteogenesis Drug Effects Alkaline Phosphatase Metabolism Animals Bone Density Administration & Dosage Collagen Cross-linking Reagents Disease Models, Animal Dose-response Relationship, Drug Drug Compounding Drug Implants Glucuronic Acid Hexuronic Acids Kinetics Lactates Mice Mice, Inbred Icr Physiopathology Polyethylene Glycols Radiography Recombinant Proteins Solubility Comparative Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Surgery Sports Science |
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