NDLI: Are race and sex associated with the occurrence of atypical femoral fractures?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Marcano, Alejandro Taormina, David Egol, Kenneth A. Peck, Valerie Tejwani, Nirmal C.
Spatial Coverage	New York City
Description	Country affiliation: United States Author Affiliation: Marcano A ( Department of Orthopaedic Surgery, New York University School of Medicine, 550 First Avenue, CD4-102, New York, NY, 10016, USA.)
Abstract	BACKGROUND: Prior studies have suggested that Asian patients and women may be more likely to sustain atypical femoral fractures in association with bisphosphonate use. However, they do not account for confounders such as asymptomatic patients who are long-term bisphosphonate users or patients sustaining osteoporotic fractures. QUESTIONS/PURPOSES: The purpose of this study was to determine the differences in sex and racial association with atypical femoral fractures by comparing demographic characteristics of patients who sustained an atypical bisphosphonate-associated fracture with patients on long-term bisphosphonates without fractures and with patients who sustained osteoporotic fractures. METHODS: Three groups from prospective registries were identified: (1) patients with atypical femur fractures associated with long-term bisphosphonate use (BFF) (n = 54); (2) patients on long-term bisphosphonates but with no associated fractures (BNF) (n = 119); and (3) patients with osteoporotic proximal femur fractures not associated with bisphosphonates (PFF) (n = 216). Age, sex, and self-reported race/ethnicity were documented and compared. Multivariate and univariate analyses were done as well as age- and sex-stratified analyses. RESULTS: Age and sex distributions of the BFF and BNF patients were similar. There was a higher percentage of Asian patients in the BFF group (17%) than in the BNF group (3%; p = 0.004) as well as Hispanics (13% versus 3% in BNF; p = 0.011). Patients in the BFF group were younger than those in the PFF group (67.5 versus 78.4 years; p < 0.001) and had fewer males (7% versus 14%; p < 0.001). CONCLUSIONS: These data suggest that Asians are at higher risk for atypical bisphosphonate-associated fractures. We recommend closer followup in Asian patients who are taking bisphosphonates. LEVEL OF EVIDENCE: Level III, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
File Format	HTM / HTML
ISSN	0009921X
e-ISSN	15281132
DOI	10.1007/s11999-013-3352-5
Journal	Clinical Orthopaedics and Related Researchtextregistered
Issue Number	3
Volume Number	472
Language	English
Publisher	Springer
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Orthopaedics Continental Population Groups Statistics & Numerical Data Femoral Fractures Ethnology African Americans Asian Americans Bone Density Conservation Agents Adverse Effects Chi-square Distribution Cross-sectional Studies Diphosphonates European Continental Ancestry Group Chemically Induced Hispanic Americans Multivariate Analysis Epidemiology Odds Ratio Osteoporosis Drug Therapy Prognosis Registries Risk Factors Sex Factors Comparative Study
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Surgery Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

CORR Insights®: Are race and sex assessment associated with the occurrence of atypical femoral fractures?

Racial/Ethnic and Sex Differences in Emergency Medical Services Transport Among Hospitalized US Stroke Patients: Analysis of the National Get With The Guidelines-Stroke Registry.

Health insurance status of US living kidney donors.

Femoral insufficiency fractures associated with prolonged bisphosphonate therapy.

Mortality in cerebral venous thrombosis: results from the national inpatient sample database.

Diversity based on race, ethnicity, and sex between academic orthopaedic surgery and other specialties: a comparative study.

Incidence of joint hypermobility syndrome in a military population: impact of gender and race.

Demographic Differences in Catheter Ablation After Hospital Presentation With Symptomatic Atrial Fibrillation.

Young Hispanic Women Experience Higher In-Hospital Mortality Following an Acute Myocardial Infarction.

Are race and sex associated with the occurrence of atypical femoral fractures?

Similar Documents

CORR Insights®: Are race and sex assessment associated with the occurrence of atypical femoral fractures?

Racial/Ethnic and Sex Differences in Emergency Medical Services Transport Among Hospitalized US Stroke Patients: Analysis of the National Get With The Guidelines-Stroke Registry.

Health insurance status of US living kidney donors.

Femoral insufficiency fractures associated with prolonged bisphosphonate therapy.

Mortality in cerebral venous thrombosis: results from the national inpatient sample database.

Diversity based on race, ethnicity, and sex between academic orthopaedic surgery and other specialties: a comparative study.

Incidence of joint hypermobility syndrome in a military population: impact of gender and race.

Demographic Differences in Catheter Ablation After Hospital Presentation With Symptomatic Atrial Fibrillation.

Young Hispanic Women Experience Higher In-Hospital Mortality Following an Acute Myocardial Infarction.

Are race and sex associated with the occurrence of atypical femoral fractures?