NDLI: Frozen section versus gross examination for bone marrow margin assessment during sarcoma resection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anderson, Megan E. Miller, Patricia E. Van Nostrand, Kelsey Vargas, Sara O.
Description	Author Affiliation: Anderson ME ( Department of Orthopaedic Surgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA, Megan.Anderson@childrens.harvard.edu.)
Abstract	BACKGROUND: Complete resection is critical for local control of primary bone sarcomas. Intraoperative consultation, including frozen section of bone marrow margins, frequently is used to aid in this goal. QUESTIONS/PURPOSES: We therefore sought to determine (1) how often intraoperative frozen section of a bone marrow margin correlates with inspection of the gross split specimen and, in cases of a discrepancy, what clinical decision is made; and (2) how well each of these assessments agrees with the final pathologic assessment of a marrow margin. METHODS: One hundred ninety-five bone marrow margins from 142 patients (74 males, 68 females; mean age, 12.8 years) with primary sarcomas who underwent resection and had frozen section(s) performed on a bone marrow margin were analyzed. Agreement between frozen section interpretation and inspection of the split gross specimen was analyzed in their application to determine adequacy of the bone marrow margin intraoperatively. RESULTS: In 179 margins, the frozen section agreed with the gross inspection decision (95.6% negative agreement, 38.5% positive agreement). Decisions regarding further surgical action in all 16 instances of disagreement were based on inspection of the split gross specimen, and the frozen section was disregarded. In 195 of 195 margins, intraoperative decisions were made based on gross specimen inspection. Full pathologic examination confirmed negative final bone marrow margins in all patients. CONCLUSIONS: Frozen section is commonly redundant or disregarded for intraoperative surgical decisions, and it may be omitted, saving operative time and cost. Examination of split gross specimens appears an adequate adjunct to clinicoradiographic assessment to achieve negative margins in the current era of modern imaging and surgical techniques. LEVEL OF EVIDENCE: Level II, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.
File Format	HTM / HTML
ISSN	0009921X
e-ISSN	15281132
DOI	10.1007/s11999-013-3005-8
Journal	Clinical Orthopaedics and Related Researchtextregistered
Issue Number	3
Volume Number	472
Language	English
Publisher	Springer
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Orthopaedics Bone Marrow Surgery Bone Neoplasms Frozen Sections Osteosarcoma Osteotomy Adolescent Pathology Child, Preschool Intraoperative Care Neoplasm, Residual Observer Variation Predictive Value Of Tests Reproducibility Of Results Unnecessary Procedures Comparative Study
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Surgery Sports Science

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