| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Franzini, Maria Lorenzoni, Valentina Masotti, Silvia Prontera, Concetta Chiappino, Dante Latta, Daniele Della Daves, Massimo Deluggi, Irene Zuin, Massimo Ferrigno, Luigina Mele, Alfonso Marcucci, Fabrizio Caserta, Carmelo A. Surace, Pasquale Messineo, Arianna Turchetti, Giuseppe Passino, Claudio Emdin, Michele Clerico, Aldo |
| Spatial Coverage |
Italy |
| Description |
Country affiliation: Italy Author Affiliation: Franzini M ( Scuola Superiora Sant'Anna, Pisa, Italy); Lorenzoni V ( Scuola Superiora Sant'Anna, Pisa, Italy.); Masotti S ( Scuola Superiora Sant'Anna, Pisa, Italy.); Prontera C ( Fondazione Toscana G. Monasterio, Pisa, Italy.); Chiappino D ( Fondazione Toscana G. Monasterio, Pisa, Italy.); Latta DD ( Fondazione Toscana G. Monasterio, Pisa, Italy.); Daves M ( Clinical Biochemical Laboratory, San Maurizio Regional Hospital, Bolzano, ltaly.); Deluggi I ( Clinical Biochemical Laboratory, San Maurizio Regional Hospital, Bolzano, ltaly.); Zuin M ( Department of lnternal Medicine and Liver Unit, School of Medicine San Paolo, University of Milan, Milan, ltaly.); Ferrigno L ( Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita', Roma, Italy.); Mele A ( Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita', Roma, Italy.); Marcucci F ( Scientific Directorate, Regina Elena Cancer Institute, Roma Italy.); Caserta CA ( Hepatology Association of Calabria, Pellaro, RC Italy.); Surace P ( Hepatology Association of Calabria, Pellaro, RC Italy.); Messineo A ( Hepatology Association of Calabria, Pellaro, RC Italy.); Turchetti G ( Scuola Superiora Sant'Anna, Pisa, Italy.); Passino C ( Fondazione Toscana G. Monasterio, Pisa, Italy.); Emdin M ( Fondazione Toscana G. Monasterio, Pisa, Italy.); Clerico A ( Scuola Superiora Sant'Anna, Pisa, Italy) |
| Abstract |
BACKGROUND: The aim of this study is to determine the 99th upper-reference limit (URL) for cardiac troponin T (cTnT) in Italian apparently healthy subjects. METHODS: The reference population was selected from 5 cities: Bolzano (n=290), Milano (CAMELIA-Study, n=287), Montignoso (MEHLP-Study, n=306), Pisa (n=182), and Reggio Calabria (MAREA-Study, n=535). Subjects having cardiac/systemic acute/chronic diseases were excluded. Participants to MEHLP project underwent cardiac imaging investigation. High-sensitive cTnT was measured with Cobas-e411 (Roche Diagnostics). RESULTS: We enrolled 1600 healthy subjects [54.6% males; age range 10-90years; mean (SD): 36.4 (21.2) years], including 34.6% aged <20years, 54.5% between 20 and 64years, and 10.9% over 65years. In the youngest the 99th URL was 10.9ng/L in males and 6.8ng/L in females; in adults 23.2ng/L and 10.2ng/L; and in elderly 36.8ng/L and 28.6ng/L. After the exclusion of outliers the 99th URL values were significantly decreased (P<0.05) in particular those of the oldest (13.8ng/L and 14ng/L). MEHLP participants were divided in healthy and asymptomatic, according to known cardiovascular risk factors (HDL, LDL, glucose, C-reactive protein): the 99th URL of cTnT values of these subgroups was significantly different (19.5 vs. 22.7, P<0.05). CONCLUSIONS: 99th URL of cTnT values was strongly affected by age, gender, selection of subjects and the statistical evaluation of outliers. |
| File Format |
HTM / HTML |
| ISSN |
00098981 |
| Volume Number |
438 |
| e-ISSN |
18733492 |
| Journal |
Clinica Chimica Acta |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-01-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Clinical Chemistry Discipline Laboratory Medicine Patient Selection Troponin T Blood Adolescent Adult Age Factors Aged Aged, 80 And Over Blood Glucose Metabolism C-reactive Protein Child Cholesterol, Hdl Cholesterol, Ldl Female Humans Italy Male Middle Aged Reference Values Risk Factors Sex Factors Journal Article Multicenter Study Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Biochemistry (medical) Clinical Biochemistry Biochemistry |
