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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Evrard, Séverine Delanaye, Pierre Kamel, Said Cristol, Jean-Paul Cavalier, Etienne |
| Description | Country affiliation: Belgium Author Affiliation: Evrard S ( Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, Liège, Belgium.); Delanaye P ( Department of Nephrology, Dialysis and Hypertension, University of Liège, CHU Sart-Tilman, Liège, Belgium.); Kamel S ( Laboratoire de Biochimie, CHU Amiens, Amiens, France); Cristol JP ( Laboratoire de Biochimie, CHRU de Montpellier, Hôpital Lapeyronie, Montpellier, France.); Cavalier E ( Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, Liège, Belgium. Electronic address: etienne.cavalier@chu.ulg.ac.be.) |
| Abstract | The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlighted more and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtedly identified as predisposing factors. But even if the process is better understood, many questions still remain unanswered. This review briefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, the main purpose of the article is to provide a profile of the various existing biomarkers of VC. Indeed, in the past years, a lot of inhibitors and promoters, which form a dense and interconnected network, were identified. Given importance to assess and control mineralization process, a focusing on accumulated knowledge of each marker seemed to be necessary. Therefore, we tried to define their respective role in the physiopathology and how they can contribute to calcification risk assessment. Among these, Klotho/fibroblast growth factor-23, fetuin-A, Matrix Gla protein, Bone morphogenetic protein-2, osteoprotegerin, osteopontin, osteonectin, osteocalcin, pyrophosphate and sclerostin are specifically discussed. |
| File Format | HTM / HTML |
| ISSN | 00098981 |
| Volume Number | 438 |
| e-ISSN | 18733492 |
| Journal | Clinica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Chemistry Discipline Laboratory Medicine Diabetes Mellitus Metabolism Dyslipidemias Renal Insufficiency, Chronic Vascular Calcification Biological Markers Bone Morphogenetic Protein 2 Genetics Calcium-binding Proteins Diabetes Complications Physiopathology Complications Extracellular Matrix Proteins Fibroblast Growth Factors Gene Expression Regulation Humans Osteoprotegerin Risk Assessment Signal Transduction Etiology Alpha-2-hs-glycoprotein Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry Biochemistry |
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