NDLI: Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bobe, Gerd Sansbury, Leah B. Albert, Paul S. Cross, Amanda J. Kahle, Lisa Ashby, Jason Slattery, Martha L. Caan, Bette Paskett, Electra Iber, Frank Kikendall, James Walter Lance, Peter Daston, Cassandra Marshall, James R. Schatzkin, Arthur Lanza, Elaine
Spatial Coverage	United States
Description	Country affiliation: United States Author Affiliation: Bobe G ( Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Room 110, Building 576, Frederick, MD 21702-1201, USA. gb246f@nih.gov)
Abstract	Two recent case-control studies suggested that some flavonoid subgroups may play a role in preventing colorectal cancer. Previous prospective cohort studies generally reported no association; however, only a small subset of flavonoids was evaluated and partial flavonoid databases were used. We used the newly constructed U.S. Department of Agriculture flavonoid database to examine the association between consumption of total flavonoids, 6 flavonoid subgroups, and 29 individual flavonoids with adenomatous polyp recurrence in the Polyp Prevention Trial. The Polyp Prevention Trial was a randomized dietary intervention trial, which examined the effectiveness of a low-fat, high-fiber, high-fruit, and high-vegetable diet on adenoma recurrence. Intakes of flavonoids were estimated from a food frequency questionnaire. Multivariate logistic regression models (adjusted for age, body mass index, sex, regular non-steroidal anti-inflammatory use, and dietary fiber intake) were used to estimate odds ratios and 95% confidence intervals for both any and advanced adenoma recurrence within quartiles of energy-adjusted flavonoid intake (baseline, during the trial, and change during the trial). Total flavonoid intake was not associated with any or advanced adenoma recurrence. However, high intake of flavonols, which are at greater concentrations in beans, onions, apples, and tea, was associated with decreased risk of advanced adenoma recurrence (4th versus 1st quartile during the trial; odds ratio, 0.24; 95% confidence interval, 0.11, 0.53; P(trend) = 0.0006). Similar inverse associations were observed to a smaller extent for isoflavonoids, the flavonol kaempferol, and the isoflavonoids genistein and formononetin. Our data suggest that a flavonol-rich diet may decrease the risk of advanced adenoma recurrence.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
DOI	10.1158/1055-9965.EPI-07-0747
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	6
Volume Number	17
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2008-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Adenoma Prevention & Control Colorectal Neoplasms Flavonoids Administration & Dosage Neoplasm Recurrence, Local Epidemiology Chi-square Distribution Logistic Models Multicenter Studies As Topic Randomized Controlled Trials As Topic Research Support, N.i.h., Intramural
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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