NDLI: Serum salicylate levels and risk of recurrent colorectal adenomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shaukat, Aasma Grau, Maria V. Church, Timothy R. Baxter, Gwen Barry, Elizabeth L. Summers, Robert Sandler, Robert S. Baron, John A.
Description	Country affiliation: United States Author Affiliation: Shaukat A ( Division of Gastroenterology, Department of Medicine and Minneapolis Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN 55417, USA. shaukat@umn.edu)
Abstract	BACKGROUND: Intake of aspirin is associated with reduction in risk of colorectal adenoma and carcinoma. Some plants contain salicylates, and individuals not taking aspirin may have measurable salicylate levels. However, the association between serum salicylate level and recurrence of adenoma in nonusers of aspirin has not been studied. METHODS: We measured serum salicylate levels in participants in a randomized controlled trial with calcium supplementation for the prevention of colorectal adenomas. Generalized linear models were used to assess the association between serum levels and adenoma risk during the follow-up period of the trial. RESULTS: We did not find an association with recurrence of adenomas or advanced adenomas with serum salicylate levels at year 1 among nonusers of aspirin. There was no effect modification of the chemopreventive effect of calcium supplementation in reducing risk of recurrent adenomas or advanced adenomas. CONCLUSIONS: Among nonusers of ASA, serum salicylate levels are not associated with risk of recurrence of adenomas. IMPACT: Serum salicylate levels can be detected in individuals not taking aspirin, but the levels may be too low to confer protection from risk of recurrent adenomas.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
DOI	10.1158/1055-9965.EPI-10-1135
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	4
Volume Number	20
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2011-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Adenoma Blood Colorectal Neoplasms Neoplasm Recurrence, Local Salicylic Acid Pathology Prevention & Control Calcium, Dietary Administration & Dosage Dietary Supplements Risk Factors Randomized Controlled Trial Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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