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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Larfors, Gunnar Hallböök, Helene Simonsson, Bengt |
| Spatial Coverage | Sweden |
| Description | Country affiliation: Sweden Author Affiliation: Larfors G ( Unit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. gunnar.larfors@ki.se) |
| Abstract | BACKGROUND: An association between childhood acute leukemia and advanced parental age was observed more than 50 years ago, and the association has been repeated in several, but not all, subsequent studies. In contrast to the many studies addressing childhood leukemia, few have included adult patients. METHODS: In this register-based case-control study, we examined the association between parental age and incidence of acute leukemia in 2,660 childhood cases and 4,412 adult cases of acute leukemia, compared with 28,288 age-matched controls selected from a population-based register. Relative risks were estimated with conditional logistic regression. RESULTS: We found a small increased risk of childhood acute lymphoblastic leukemia with increasing paternal age (adjusted OR, 1.05 per 5-year increase in age). Risk estimates were similar for childhood acute myeloid leukemia (AML), whereas no association was found with adult leukemia. Meanwhile, we observed a decreased risk of adult AML with increasing number of siblings, both older and younger. CONCLUSIONS: The results support the idea of a prenatal etiology of leukemia but indicate that parental age effects are limited to childhood cases. IMPACT: This is the first large study on parental age and leukemia risk, which includes adult cases. The finding on family size and risk of adult AML needs to be validated in future studies. |
| File Format | HTM / HTML |
| ISSN | 10559965 |
| e-ISSN | 15387755 |
| Journal | Cancer Epidemiology Biomarkers & Prevention |
| Issue Number | 7 |
| Volume Number | 21 |
| Language | English |
| Publisher | American Association for Cancer Research |
| Publisher Date | 2012-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cancer epidemiology Family Characteristics Leukemia, Myeloid, Acute Etiology Precursor Cell Lymphoblastic Leukemia-lymphoma Prenatal Exposure Delayed Effects Adolescent Case-control Studies Down Syndrome Complications Epidemiology Pregnancy Prognosis Registries Risk Factors Sweden Comparative Study Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Epidemiology Oncology |
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