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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Boere, E. Birkenhäger, T. K. Groenland, T. H. N. Van Den Broek, W. W. |
| Description | Country affiliation: Netherlands Author Affiliation: Boere E ( Department of Psychiatry, Erasmus Medical Centre, PO Box 2040, Rotterdam 3000 CA, The Netherlands e.boere@yahoo.com.); Birkenhäger TK ( Department of Psychiatry, Erasmus Medical Centre, PO Box 2040, Rotterdam 3000 CA, The Netherlands.); Groenland TH ( Department of Anaesthesiology, Erasmus Medical Centre, PO Box 2040, Rotterdam 3000 CA, The Netherlands.); van den Broek WW ( Department of Psychiatry, Erasmus Medical Centre, PO Box 2040, Rotterdam 3000 CA, The Netherlands.) |
| Abstract | Electroconvulsive therapy (ECT) is associated with at least transient episodes of hypertension and tachycardia. Beta-blocking agents may be indicated to prevent cardiovascular complications and may shorten seizure duration. This review evaluates studies that used beta-blocking agents during ECT to determine which agent has the most favourable outcomes on cardiovascular variables and seizure duration. A Medline database search was made using the combined keywords 'adrenergic beta-antagonists' and 'electroconvulsive therapy'. The search was restricted to double-blind randomized controlled trials and yielded 29 original studies. With the use of esmolol, significant attenuating effects were found on cardiovascular parameters in the first 5 min after stimulation; its shortening effects on seizure duration may be dose-related. With the use of labetalol, findings on cardiovascular effects were inconsistent during the first minutes after stimulation but were significant after 5 min and thereafter; seizure duration was scarcely studied. Landiolol attenuates heart rate but with inconsistent findings regarding arterial pressure (AP); seizure duration was mostly unaffected. Esmolol appears to be effective in reducing the cardiovascular response, although seizure duration may be affected with higher dosages. Landiolol can be considered a suitable alternative, but effects on AP need further investigation. Labetalol has been studied to a lesser extent and may have prolonged cardiovascular effects. The included studies varied in design, methodology, and the amount of exact data provided in the publications. Further study of beta-blocking agents in ECT is clearly necessary. |
| File Format | HTM / HTML |
| ISSN | 00070912 |
| e-ISSN | 14716771 |
| Journal | British Journal of Anaesthesia |
| Issue Number | 1 |
| Volume Number | 113 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2014-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Anesthesiology Adrenergic Beta-antagonists Therapeutic Use Cardiovascular Diseases Prevention & Control Electroconvulsive Therapy Adverse Effects Etiology Labetalol Morpholines Propanolamines Randomized Controlled Trials As Topic Urea Analogs & Derivatives |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
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